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Verfasst von:Hackl, Norman J. [VerfasserIn]   i
 Bersch, Claus [VerfasserIn]   i
 Feick, Peter [VerfasserIn]   i
 Antoni, Christoph Helmer [VerfasserIn]   i
 Franke, Andreas [VerfasserIn]   i
 Singer, Manfred V. [VerfasserIn]   i
 Nakchbandi, Inaam [VerfasserIn]   i
Titel:Circulating fibronectin isoforms predict the degree of fibrosis in chronic hepatitis C
Verf.angabe:Norman J. Hackl, Claus Bersch, Peter Feick, Christoph Antoni, Andreas Franke, Manfred V. Singer & Inaam A. Nakchbandi
Jahr:2010
Umfang:8 S.
Fussnoten:Gesehen am 28.06.2021
Titel Quelle:Enthalten in: Scandinavian journal of gastroenterology
Ort Quelle:Abingdon : Taylor & Francis Group, 1966
Jahr Quelle:2010
Band/Heft Quelle:45(2010), 3, Seite 349-356
ISSN Quelle:1502-7708
Abstract:OBJECTIVE: Hepatic stellate cells only produce fibronectin isoforms in disease states. The isoform-defining domains can be detected in the blood circulation. This study examines whether circulating levels of fibronectin isoforms show a relationship with liver fibrosis on histology in patients with chronic hepatitis C. MATERIAL AND METHODS: In a prospective study, 50 patients with chronic hepatitis C who underwent a liver biopsy were compared to 50 matched controls and 35 patients with other liver conditions. RESULTS: Circulating levels of the fibronectin isoforms were significantly higher in patients with chronic hepatitis C compared to healthy controls [oncofetal fibronectin (oFN) 2.45 +/- 0.17 versus 1.76 +/- 0.16 mg/l, P < 0.005; extra domain-A (EDA) 1.05 +/- 0.06 versus 0.86 +/- 0.06 mg/l, P < 0.05; and extra domain-B (EDB) 14.55 +/- 0.74 versus 9.31 +/- 0.58 mg/l, P < 0.001], even though total fibronectin was lower (198.9 +/- 3.5 versus 343.6 +/- 14.5 mg/l, P < 0.001). A correlation with the fibrosis score was found for both oFN (r = 0.46, P < 0.005) and EDA (r = 0.51, P < 0.001). The combination of an elevation in both markers (oFN and EDA) in the upper quartile was associated with a specificity of > 99% for predicting significant fibrosis (stages 2-4) and 95% for predicting advanced fibrosis (stages 3-4). A combination of decreased values in the lowest tertile for both markers had a specificity of 94% for excluding significant fibrosis. Based on these findings, 30% of the patients scheduled for a liver biopsy could be correctly classified as having or not having significant fibrosis. The remainder would have to proceed with a biopsy. CONCLUSION: Circulating fibronectin isoforms produced by activated stellate cells represent a viable marker for the presence of significant fibrosis or a lack thereof.
DOI:doi:10.3109/00365520903490606
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3109/00365520903490606
 DOI: https://doi.org/10.3109/00365520903490606
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult
 Biomarkers
 Biopsy, Needle
 Case-Control Studies
 Cross-Sectional Studies
 Female
 Fibronectins
 Hepatic Stellate Cells
 Hepatitis C, Chronic
 Humans
 Liver Cirrhosis
 Male
 Middle Aged
 Predictive Value of Tests
 Protein Isoforms
K10plus-PPN:1761391011
Verknüpfungen:→ Zeitschrift

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