| |  Online-Ressource |
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| Verfasst von: | Triana, Sergio [VerfasserIn]  |
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| | Metz Zumarán, Camila [VerfasserIn] |
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| | Ramirez, Carlos [VerfasserIn] |
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| | Kee, Carmon [VerfasserIn] |
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| | Doldan, Patricio [VerfasserIn] |
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| | Shahraz, Mohammed [VerfasserIn] |
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| | Schraivogel, Daniel [VerfasserIn] |
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| | Gschwind, Andreas R [VerfasserIn] |
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| | Sharma, Ashwini Kumar [VerfasserIn] |
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| | Steinmetz, Lars M [VerfasserIn] |
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| | Herrmann, Carl [VerfasserIn] |
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| | Alexandrov, Theodore [VerfasserIn] |
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| | Boulant, Steeve [VerfasserIn] |
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| | Stanifer, Megan [VerfasserIn] |
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| Titel: | Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut |
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| Verf.angabe: | Sergio Triana, Camila Metz-Zumaran, Carlos Ramirez, Carmon Kee, Patricio Doldan, Mohammed Shahraz, Daniel Schraivogel, Andreas R. Gschwind, Ashwini K.Sharma, Lars M. Steinmetz, Carl Herrmann, Theodore Alexandrov, Steeve Boulant & Megan L. Stanifer |
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| Jahr: | 2021 |
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| Umfang: | 25 S. |
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| Fussnoten: | Gesehen am 30.06.2021 |
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| Titel Quelle: | Enthalten in: Molecular systems biology |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2005 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 17(2021), 4, Artikel-ID e10232, Seite 1-25 |
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| ISSN Quelle: | 1744-4292 |
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| Abstract: | Abstract Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids. We identified a subpopulation of enterocytes as the prime target of SARS-CoV-2 and, interestingly, found the lack of positive correlation between susceptibility to infection and the expression of ACE2. Infected cells activated strong pro-inflammatory programs and produced interferon, while expression of interferon-stimulated genes was limited to bystander cells due to SARS-CoV-2 suppressing the autocrine action of interferon. These findings reveal that SARS-CoV-2 curtails the immune response and highlights the gut as a pro-inflammatory reservoir that should be considered to fully understand SARS-CoV-2 pathogenesis. |
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| DOI: | doi:10.15252/msb.202110232 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15252/msb.202110232 |
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| | Volltext: https://www.embopress.org/doi/full/10.15252/msb.202110232 |
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| | DOI: https://doi.org/10.15252/msb.202110232 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | human intestinal epithelial cells |
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| | interferon |
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| | intrinsic immune response |
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| | SARS-CoV-2 |
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| | single-cell RNA sequencing |
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| K10plus-PPN: | 1761607693 |
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| Verknüpfungen: | → Zeitschrift |
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Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut / Triana, Sergio [VerfasserIn]; 2021 (Online-Ressource)
