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Verfasst von:Wagner, Christof [VerfasserIn]   i
 Aytaç, Sâra [VerfasserIn]   i
 Hänsch, Gertrud Maria [VerfasserIn]   i
Titel:Biofilm growth on implants
Titelzusatz:bacteria prefer plasma coats
Verf.angabe:Christof Wagner, Sara Aytac, G. Maria Hänsch
E-Jahr:2011
Jahr:November 17, 2011
Umfang:7 S.
Fussnoten:Gesehen am 30.06.2021
Titel Quelle:Enthalten in: The international journal of artificial organs
Ort Quelle:Thousand Oaks, CA : Sage Publishing, 1978
Jahr Quelle:2011
Band/Heft Quelle:34(2011), 9, Seite 811-817
ISSN Quelle:1724-6040
Abstract:PURPOSE: Bacterial biofilm formation on prostheses or devices used for osteosynthesis is increasingly recognized as cause of persistent infections, an entity known as implant-associated posttraumatic osteomyelitis. Biofilm formation is a very complex, multistep process with adhesion as the first and decisive step. The most prevalent pathogens found are staphylococci species, especially S. aureus, presumably due to a preference to non-biological materials, such as metal. Adherence is influenced by several factors, including the microenvironment, in which blood proteins from serum or plasma might influence adhesion and maybe biofilm formation. The aim of the present study was to test and to compare adherence of S. aureus and P. aeruginosa to different biological and non-biological surfaces in vitro. The question was addressed if coating of the surface by plasma or serum proteins influences bacterial adherence. METHODS: Adherence of radiolabeled bacteria to different surfaces in the presence or absence or serum/plasma proteins was measured over time. RESULTS: When testing adherence of S. aureus to plastic, titanium or to monolayers of epithelial cells (A549) or fibroblasts (Colo800) a clear-cut preference for non-biological surfaces, especially for titanium was seen. Using P. aeruginosa species a similar pattern without a significant difference was revealed. When mimicking the in vivo situation by pre-coating of titanium with human serum or plasma adherence was increased, especially when titanium was coated ("opsonized") by plasma. CONCLUSIONS: Bacterial adherence to surfaces is determined by a variety of factors such as temperature, the presence of nutrients, the absence of host defense systems and the configuration of the covered surface. In vivo, adherence to non-biological surfaces is also influenced by the microenvironment, especially plasma proteins, promoting biofilm formation.
DOI:doi:10.5301/ijao.5000061
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.5301/ijao.5000061
 Volltext: https://journals.sagepub.com/doi/10.5301/ijao.5000061?url_ver=Z39.88-2003
 DOI: https://doi.org/10.5301/ijao.5000061
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Bacterial Adhesion
 Biofilms
 Blood Proteins
 Cell Line, Tumor
 Coated Materials, Biocompatible
 Humans
 Joint Prosthesis
 Polystyrenes
 Prosthesis Design
 Pseudomonas aeruginosa
 Staphylococcus aureus
 Surface Properties
 Time Factors
 Titanium
K10plus-PPN:1761623737
Verknüpfungen:→ Zeitschrift

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