Pediatric herpes simplex virus encephalitis

• Verfasst von: Schleede, Lena
• Titel: Pediatric herpes simplex virus encephalitis
• Titelzusatz: a retrospective multicenter experience
• Mitwirkende: Büter, Wolfgang
• Mitwirkende: Baumgartner-Sigl, Sara
• Mitwirkende: Opladen, Thomas
• Mitwirkende: Weigt-Usinger, Katharina
• Mitwirkende: Stephan, Susanne
• Mitwirkende: Smitka, Martin
• Mitwirkende: Leiz, Steffen
• Mitwirkende: Kaiser, Olaf
• Mitwirkende: Kraus, Verena
• Mitwirkende: Baalen, Andreas van
• Mitwirkende: Skopnik, Heino
• Mitwirkende: Hartmann, Hans
• Mitwirkende: Rostasy, Kevin
• Mitwirkende: Lücke, Thomas
• Mitwirkende: Schara, Ulrike
• Mitwirkende: Häusler, Martin
• Verf.angabe: Lena Schleede, Wolfgang Bueter, Sara Baumgartner-Sigl, Thomas Opladen, Katharina Weigt-Usinger, Susanne Stephan, Martin Smitka, Steffen Leiz, Olaf Kaiser, Verena Kraus, Andreas van Baalen, Heino Skopnik, Hans Hartmann, Kevin Rostasy, Thomas Lu ̈cke, Ulrike Schara, and Martin Häusler
• E-Jahr: 2013
• Jahr: January 16, 2013
• Umfang: 11 S.
• Teil: volume:28
• Teil: year:2013
• Teil: number:3
• Teil: pages:321-331
• Teil: extent:11
• Fussnoten: Gesehen am 01.07.2021
• Titel Quelle: In: Journal of child neurology
• Ort Quelle: Thousand Oaks, Calif. : Sage, 1986
• Jahr Quelle: 2013
• Band/Heft Quelle: 28(2013), 3, Seite 321-331
• ISSN Quelle: 1708-8283
• DOI: doi:10.1177/0883073812471428
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 77395984X

Abstract

Knowledge on pediatric herpes simplex virus encephalitis is limited. Here we summarize 6 neonates and 32 children diagnosed bypolymerase chain reaction (n=37) or serological studies (n=1), respectively. Diagnosis was difficult, as only 15 patientspresented neurologic symptoms. Moreover, cerebrospinal fluid glucose, protein, and leukocytes were normal in 6 patients.Subsequently, all but 2 showed neurologic symptoms. Diffusion-weighted neuroimaging was the most sensitive early imagingmethod. Despite acyclovir treatment, 8 patients experienced early relapses, showing movement abnormalities, impaired vigilance,and seizures. Diffuse white matter changes, found in 3 of 5 relapse patients on neuroimaging, and a negative cerebrospinal fluidherpes simplex virus polymerase chain reaction suggested inflammatory processes. All relapse patients were again treated withacyclovir, and 3 responded to additional corticosteroid treatment. Whereas outcome after relapses was poor, overall outcomewas good. No child died; 14 were asymptomatic at discharge, and neuroimaging remained normal in 7 of 30 patients studied.