How to assess non-calcified plaque in CT angiography

• Verfasst von: Schlett, Christopher L. [VerfasserIn]
• Verfasst von: Ferencik, Maros [VerfasserIn]
• Verfasst von: Celeng, Csilla [VerfasserIn]
• Verfasst von: Maurovich-Horvat, Pál [VerfasserIn]
• Verfasst von: Scheffel, Hans [VerfasserIn]
• Verfasst von: Stolzmann, Paul [VerfasserIn]
• Verfasst von: Do, Synho [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Alkadhi, Hatem [VerfasserIn]
• Verfasst von: Bamberg, Fabian [VerfasserIn]
• Verfasst von: Hoffmann, Udo [VerfasserIn]
• Titel: How to assess non-calcified plaque in CT angiography
• Titelzusatz: delineation methods affect diagnostic accuracy of low-attenuation plaque by CT for lipid-core plaque in histology
• Verf.angabe: Christopher L. Schlett, Maros Ferencik, Csilla Celeng, Pál Maurovich-Horvat, Hans Scheffel, Paul Stolzmann, Synho Do, Hans-Ulrich Kauczor, Hatem Alkadhi, Fabian Bamberg, and Udo Hoffmann
• E-Jahr: 2013
• Jahr: 12 May 2013
• Umfang: 7 S.
• Teil: volume:14
• Teil: year:2013
• Teil: number:11
• Teil: pages:1099-1105
• Teil: extent:7
• Fussnoten: Gesehen am 01.07.2021
• Titel Quelle: Enthalten in: European heart journal - cardiovascular imaging
• Ort Quelle: Oxford : Oxford University Press, 2012
• Jahr Quelle: 2013
• Band/Heft Quelle: 14(2013), 11, Seite 1099-1105
• ISSN Quelle: 2047-2412
• DOI: doi:10.1093/ehjci/jet030
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 176172018X

Abstract

To compare the accuracy of two plaque delineation methods for coronary computed tomographic angiography (CTA) to identify lipid-core plaque (LCP) using histology as the reference standard.Five ex vivo hearts were analysed by CTA and histology. LCP was defined by histology as fibroatheroma with core diameter/circumference >200 μm/>60° and cap thickness <450 μm. In CTA, plaque was manually delineated either as the difference between the inner and outer vessel walls (Method A) or as a direct tracing of plaque (Method B). Low-attenuation plaque was defined as an area with <90 Hounsfield units. Of 446 co-registered cross-sections, 55 (12%) contained LCP. In CTA, low-attenuation plaque area was larger as assessed with Method A compared with Method B (difference: 120 ± 60%). Although low-attenuation plaque was associated with the presence of LCP, the delineation Method B yielded higher diagnostic accuracy than Method A [area under the curve (AUC): 0.831 vs. 0.780, respectively, P = 0.005]. After excluding ‘normal’ cross-sections by CTA (n = 117), AUC for detecting LCP became similar between both methods (0.767 vs. 0.729, P = 0.07, respectively).Low-attenuation plaque in CTA is a diagnostic tool for LCP but prone to error if plaque is defined as the area between the inner and outer vessel walls and normal cross-sections are included in the assessment.