| |  Online-Ressource |
|---|
| Verfasst von: | Kohrs, Friederike [VerfasserIn]  |
|---|
| | Daumann, Ilsa-Maria [VerfasserIn] |
|---|
| | Pavlović, Bojana [VerfasserIn] |
|---|
| | Jin, Eugene Jennifer [VerfasserIn] |
|---|
| | Kiral, F Ridvan [VerfasserIn] |
|---|
| | Lin, Shih-Ching [VerfasserIn] |
|---|
| | Port, Fillip [VerfasserIn] |
|---|
| | Wolfenberg, Heike [VerfasserIn] |
|---|
| | Mathejczyk, Thomas F [VerfasserIn] |
|---|
| | Linneweber, Gerit A [VerfasserIn] |
|---|
| | Chan, Chih-Chiang [VerfasserIn] |
|---|
| | Boutros, Michael [VerfasserIn] |
|---|
| | Hiesinger, P Robin [VerfasserIn] |
|---|
| Titel: | Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies |
|---|
| Verf.angabe: | Friederike E Kohrs, Ilsa-Maria Daumann, Bojana Pavlovic, Eugene Jennifer Jin, F Ridvan Kiral, Shih-Ching Lin, Filip Port, Heike Wolfenberg, Thomas F Mathejczyk, Gerit A Linneweber, Chih-Chiang Chan, Michael Boutros, P Robin Hiesinger |
|---|
| E-Jahr: | 2021 |
|---|
| Jahr: | 05 March 2021 |
|---|
| Umfang: | 37 S. |
|---|
| Fussnoten: | Gesehen am 03.07.2021 |
|---|
| Titel Quelle: | Enthalten in: eLife |
|---|
| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 10(2021), Artikel-ID e59594, Seite 1-37 |
|---|
| ISSN Quelle: | 2050-084X |
|---|
| Abstract: | Rab GTPases are molecular switches that regulate membrane trafficking in all cells. Neurons have particular demands on membrane trafficking and express numerous Rab GTPases of unknown function. Here, we report the generation and characterization of molecularly defined null mutants for all 26 rab genes in Drosophila. In flies, all rab genes are expressed in the nervous system where at least half exhibit particularly high levels compared to other tissues. Surprisingly, loss of any of these 13 nervous system-enriched Rabs yielded viable and fertile flies without obvious morphological defects. However, all 13 mutants differentially affected development when challenged with different temperatures, or neuronal function when challenged with continuous stimulation. We identified a synaptic maintenance defect following continuous stimulation for six mutants, including an autophagy-independent role of rab26. The complete mutant collection generated in this study provides a basis for further comprehensive studies of Rab GTPases during development and function in vivo. |
|---|
| DOI: | doi:10.7554/eLife.59594 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.59594 |
|---|
| | DOI: https://doi.org/10.7554/eLife.59594 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Drosophila |
|---|
| | mutant collection |
|---|
| | Rab GTPase |
|---|
| K10plus-PPN: | 1761848925 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Systematic functional analysis of rab GTPases reveals limits of neuronal robustness to environmental challenges in flies / Kohrs, Friederike [VerfasserIn]; 05 March 2021 (Online-Ressource)
