| |  Online-Ressource |
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| Verfasst von: | Zhang, Xin-Wen [VerfasserIn]  |
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| | Huck, Katrin [VerfasserIn] |
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| | Jähne, Kristine [VerfasserIn] |
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| | Cichon, Frederik [VerfasserIn] |
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| | Sonner, Jana K. [VerfasserIn] |
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| | Ufer, Friederike [VerfasserIn] |
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| | Bauer, Simone [VerfasserIn] |
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| | Woo, Marcel Seungsu [VerfasserIn] |
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| | Green, Edward W. [VerfasserIn] |
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| | Lu, Kevin Hai-Ning [VerfasserIn] |
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| | Kilian, Michael [VerfasserIn] |
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| | Friese, Manuel A. [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Sahm, Katharina [VerfasserIn] |
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| Titel: | Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma |
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| Verf.angabe: | Xin-Wen Zhang, Katrin Huck, Kristine Jähne, Frederik Cichon, Jana K. Sonner, Friederike Ufer, Simone Bauer, Marcel Seungsu Woo, Ed Green, Kevin Lu, Michael Kilian, Manuel A. Friese, Michael Platten and Katharina Sahm |
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| E-Jahr: | 2021 |
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| Jahr: | 14 May 2021 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 08.07.2021 |
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| Titel Quelle: | Enthalten in: OncoImmunology |
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| Ort Quelle: | Abingdon : Taylor & Franics, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 10(2021), Artikel-ID 1920739, Seite 1-14 |
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| ISSN Quelle: | 2162-402X |
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| Abstract: | Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within the tumor microenvironment promotes adaptive antitumor immunity, enhancement of DC migration toward the tumor microenvironment following DC vaccination might represent one possible approach to increase its therapeutic efficacy. While recent findings suggest the activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) as critical regulator of DC migration in the context of autoimmune diseases, we aimed to investigate the impact of Arc/Arg3.1 expression for DC-based cancer vaccines.To this end, DC migration capacity as well as the induction of T cell-mediated antitumor immunity was assessed in an experimental B16 melanoma model with Arc/Arg3.1−/- and Arc/Arg3.1-expressing BMDCs applied as a subcutaneous vaccine.While antigen presentation on DCs was critical for unleashing effective T cell mediated antitumor immune responses, Arc/Arg3.1 expression enhanced DC migration toward the tumor and secondary lymphoid organs. Moreover, Arc/Arg3.1-expressing BMDCs shape the tumor immune microenvironment by facilitating tumor recruitment of antigen-specific effector T cells.Thus, Arc/Arg3.1 may represent a novel therapeutic target in DCs in order to increase the therapeutic efficacy of DC vaccination. |
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| DOI: | doi:10.1080/2162402X.2021.1920739 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/2162402X.2021.1920739 |
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| | DOI: https://doi.org/10.1080/2162402X.2021.1920739 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adoptive immunotherapy |
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| | CD8-positive T-lymphocytes |
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| | dendritic cells |
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| | melanoma |
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| | tumor microenvironment |
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| K10plus-PPN: | 176247879X |
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| Verknüpfungen: | → Zeitschrift |
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Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma / Zhang, Xin-Wen [VerfasserIn]; 14 May 2021 (Online-Ressource)
