Mechanisms of cotranslational protein maturation in bacteria

• Verfasst von: Koubek, Jiří [VerfasserIn]
• Verfasst von: Schmitt, Jaro [VerfasserIn]
• Verfasst von: Galmozzi, Carla [VerfasserIn]
• Verfasst von: Kramer, Günter [VerfasserIn]
• Titel: Mechanisms of cotranslational protein maturation in bacteria
• Verf.angabe: Jiří Koubek, Jaro Schmitt, Carla Veronica Galmozzi and Günter Kramer
• E-Jahr: 2021
• Jahr: 25 May 2021
• Umfang: 15 S.
• Teil: volume:8
• Teil: year:2021
• Teil: day:25
• Teil: month:05
• Teil: elocationid:689755
• Teil: extent:15
• Fussnoten: Gesehen am 09.07.2021
• Titel Quelle: Enthalten in: Frontiers in molecular biosciences
• Ort Quelle: Lausanne : Frontiers, 2014
• Jahr Quelle: 2021
• Band/Heft Quelle: 8(2021) vom: 25. Mai, Artikel-ID 689755
• ISSN Quelle: 2296-889X
• DOI: doi:10.3389/fmolb.2021.689755
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: chaperone recognition
• Sach-SW: Cotranslational assembly
• Sach-SW: DnaK
• Sach-SW: Nascent chain processing
• Sach-SW: Protein Folding
• Sach-SW: ribosomal exit tunnel
• Sach-SW: Trigger Factor
• K10plus-PPN: 1762634031
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Growing cells invest a significant part of their biosynthetic capacity into the production of proteins. To become functional, newly-synthesized proteins must be N-terminally processed, folded and often translocated to other cellular compartments. A general strategy is to integrate these protein maturation processes with translation, by cotranslationally engaging processing enzymes, chaperones and targeting factors with the nascent polypeptide. Precise coordination of all factors involved is critical for the efficiency and accuracy of protein synthesis and cellular homeostasis. This review provides an overview of the current knowledge on cotranslational protein maturation, with a focus on the production of cytosolic proteins in bacteria. We describe the role of the ribosome and the chaperone network in protein folding and how the dynamic interplay of all cotranslationally acting factors guides the sequence of cotranslational events. Finally, we discuss recent data demonstrating the coupling of protein synthesis with the assembly of protein complexes and end with a brief discussion of outstanding questions and emerging concepts in the field of cotranslational protein maturation.