Vitamin D and cardiovascular disease

• Verfasst von: Zittermann, Armin [VerfasserIn]
• Verfasst von: Trummer, Christian [VerfasserIn]
• Verfasst von: Theiler-Schwetz, Verena [VerfasserIn]
• Verfasst von: Lerchbaum, Elisabeth [VerfasserIn]
• Verfasst von: März, Winfried [VerfasserIn]
• Verfasst von: Pilz, Stefan [VerfasserIn]
• Titel: Vitamin D and cardiovascular disease
• Titelzusatz: An updated narrative review
• Verf.angabe: Armin Zittermann, Christian Trummer, Verena Theiler-Schwetz, Elisabeth Lerchbaum, Winfried März and Stefan Pilz
• E-Jahr: 2021
• Jahr: 12 March 2021
• Umfang: 18 S.
• Fussnoten: Gesehen am 12.07.2021
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2021
• Band/Heft Quelle: 22(2021), 6, Artikel-ID 2896, Seite 1-18
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms22062896
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: atherosclerosis
• Sach-SW: calcium
• Sach-SW: cardiovascular
• Sach-SW: chronic kidney disease
• Sach-SW: epidemiology
• Sach-SW: heart
• Sach-SW: mortality
• Sach-SW: vitamin D
• Sach-SW: vitamin D receptor
• K10plus-PPN: 1762696401

Abstract

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. In patients with rickets and osteomalacia, cardiovascular complications are infrequently reported, except for an increased risk of heart failure. In conclusion, there is no strong evidence for beneficial vitamin D effects on CVD risk, either in the general population or in high-risk groups. Whether some subgroups such as individuals with severe vitamin D deficiency or a combination of low vitamin D status with specific gene variants and/or certain nutrition/lifestyle factors would benefit from vitamin D (metabolite) administration, remains to be studied.