| |  Online-Ressource |
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| Verfasst von: | Wu, Li [VerfasserIn]  |
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| | Han, Yuqiu [VerfasserIn] |
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| | Zheng, Zhipeng [VerfasserIn] |
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| | Zhu, Shuai [VerfasserIn] |
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| | Chen, Jun [VerfasserIn] |
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| | Yao, Yuanyuan [VerfasserIn] |
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| | Yue, Siqing [VerfasserIn] |
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| | Teufel, Andreas [VerfasserIn] |
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| | Weng, Honglei [VerfasserIn] |
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| | Li, Lanjuan [VerfasserIn] |
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| | Wang, Baohong [VerfasserIn] |
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| Titel: | Obeticholic acid inhibits anxiety via alleviating gut microbiota-mediated microglia accumulation in the brain of high-fat high-sugar diet mice |
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| Verf.angabe: | Li Wu, Yuqiu Han, Zhipeng Zheng, Shuai Zhu, Jun Chen, Yuanyuan Yao, Siqing Yue, Andreas Teufel, Honglei Weng, Lanjuan Li and Baohong Wang |
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| E-Jahr: | 2021 |
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| Jahr: | 15 March 2021 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 13.07.2021 |
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| Titel Quelle: | Enthalten in: Nutrients |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 3, Artikel-ID 940, Seite 1-21 |
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| ISSN Quelle: | 2072-6643 |
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| Abstract: | Anxiety is one of the complications of metabolic disorders (MDs). Obeticholic acid (OCA), the bile acids (BAs) derivative, is a promising agent for improving MDs in association with gut dysbiosis. Yet, its protective effect on MDs-driven anxiety remains unknown. Here, we assessed the serum biochemical parameters and behavioral performance by open field and Morris water maze tests in HFHS diet-induced MDs mice after OCA intervention for nine and 18 weeks. Moreover, antibiotics intervention for microbial depletion was conducted simultaneously. We found that OCA treatment inhibited the initiation and progression of anxiety in HFHS diet-MDs mice via a microbiota-BAs-brain axis: OCA decreased the neuroinflammatory microglia and IL-1β expression in the hippocampus, reversed intestinal barrier dysfunction and serum proinflammatory LPS to a normal level, modified the microbial community, including the known anxiety-related Rikenellaceae and Alistipes, and improved the microbial metabolites especially the increased BAs in feces and circulation. Moreover, the OCA-reversed bile acid taurocholate linked disordered serum lipid metabolites and indole derivatives to anxiety as assessed by network analysis. Additionally, microbial depletion with antibiotics also improved the anxiety, microgliosis and BAs enrichment in the experimental MDs mice. Together, these findings provide microbiota-BAs-brain axis as a novel therapeutic target for MDs-associated neuropsychiatric disorders. |
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| DOI: | doi:10.3390/nu13030940 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/nu13030940 |
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| | Volltext: https://www.mdpi.com/2072-6643/13/3/940 |
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| | DOI: https://doi.org/10.3390/nu13030940 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anxiety |
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| | bile acids |
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| | gut microbiota |
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| | metabolic disorders |
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| | neuroinflammation |
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| | obeticholic acid |
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| K10plus-PPN: | 1762737248 |
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| Verknüpfungen: | → Zeitschrift |
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Obeticholic acid inhibits anxiety via alleviating gut microbiota-mediated microglia accumulation in the brain of high-fat high-sugar diet mice / Wu, Li [VerfasserIn]; 15 March 2021 (Online-Ressource)
