Different genotypes of Brugada syndrome may present different clinical phenotypes

• Verfasst von: El-Battrawy, Ibrahim [VerfasserIn]
• Verfasst von: Lang, Siegfried [VerfasserIn]
• Verfasst von: Zhou, Xiao-Bo [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: Different genotypes of Brugada syndrome may present different clinical phenotypes
• Titelzusatz: electrophysiology from bench to bedside
• Verf.angabe: Ibrahim El-Battrawy, Siegfried Lang, Xiaobo Zhou, and Ibrahim Akin
• E-Jahr: 2021
• Jahr: 17 February 2021
• Umfang: 3 S.
• Fussnoten: Gesehen am 13.07.2021
• Titel Quelle: Enthalten in: European heart journal
• Ort Quelle: Oxford : Oxford University Press, 1980
• Jahr Quelle: 2021
• Band/Heft Quelle: 42(2021), 13, Seite 1270-1272
• ISSN Quelle: 1522-9645
• DOI: doi:10.1093/eurheartj/ehab070
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1762743086

Abstract

This commentary refers to ‘Brugada syndrome genetics is associated with phenotype severity’ by G. Ciconte et al., doi: 10.1093/eurheartj/ehaa942 and the discussion piece ‘Common modulators of Brugada syndrome phenotype do not affect SCN5A prognostic value’ by C. Pappone et al., doi:10.1093/eurheartj/ehab071.The article by Ciconte et al.1 published in the European Heart Journal describing the relevance of genetic background on the clinical phenotype of Brugada syndrome (BrS) elucidated great interest among researcher of our working group. Authors showed that electrophysiological abnormalities in BrS are determined by the genetic background. Carriers of SCN5A mutations exhibited more pronounced epicardial abnormalities and more aggressive clinical presentation.