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| Verfasst von: | Höhn, Julia [VerfasserIn]  |
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| | Krieghoff-Henning, Eva [VerfasserIn] |
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| | Jutzi, Tanja [VerfasserIn] |
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| | Kalle, Christof von [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Meier, Friedegund [VerfasserIn] |
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| | Gellrich, Frank F. [VerfasserIn] |
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| | Hobelsberger, Sarah [VerfasserIn] |
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| | Hauschild, Axel [VerfasserIn] |
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| | Schlager, Justin G. [VerfasserIn] |
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| | French, Lars [VerfasserIn] |
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| | Heinzerling, Lucie [VerfasserIn] |
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| | Schlaak, Max [VerfasserIn] |
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| | Ghoreschi, Kamran [VerfasserIn] |
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| | Hilke, Franz J. [VerfasserIn] |
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| | Poch, Gabriela [VerfasserIn] |
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| | Kutzner, Heinz [VerfasserIn] |
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| | Heppt, Markus V. [VerfasserIn] |
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| | Haferkamp, Sebastian [VerfasserIn] |
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| | Sondermann, Wiebke [VerfasserIn] |
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| | Schadendorf, Dirk [VerfasserIn] |
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| | Schilling, Bastian [VerfasserIn] |
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| | Goebeler, Matthias [VerfasserIn] |
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| | Hekler, Achim [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Lipka, Daniel [VerfasserIn] |
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| | Kather, Jakob Nikolas [VerfasserIn] |
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| | Krahl, Dieter [VerfasserIn] |
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| | Ferrara, Gerardo [VerfasserIn] |
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| | Haggenmüller, Sarah [VerfasserIn] |
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| | Brinker, Titus Josef [VerfasserIn] |
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| Titel: | Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification |
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| Verf.angabe: | Julia Höhn, Eva Krieghoff-Henning, Tanja B. Jutzi, Christof von Kalle, Jochen S. Utikal, Friedegund Meier, Frank F. Gellrich, Sarah Hobelsberger, Axel Hauschild, Justin G. Schlager, Lars French, Lucie Heinzerling, Max Schlaak, Kamran Ghoreschi, Franz J. Hilke, Gabriela Poch, Heinz Kutzner, Markus V. Heppt, Sebastian Haferkamp, Wiebke Sondermann, Dirk Schadendorf, Bastian Schilling, Matthias Goebeler, Achim Hekler, Stefan Fröhling, Daniel B. Lipka, Jakob N. Kather, Dieter Krahl, Gerardo Ferrara, Sarah Haggenmüller, Titus J. Brinker |
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| E-Jahr: | 2021 |
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| Jahr: | 7 April 2021 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 13.07.2021 |
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| Titel Quelle: | Enthalten in: European journal of cancer |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 149(2021) vom: Mai, Seite 94-101 |
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| ISSN Quelle: | 1879-0852 |
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| Abstract: | Background - Clinicians and pathologists traditionally use patient data in addition to clinical examination to support their diagnoses. - Objectives - We investigated whether a combination of histologic whole slides image (WSI) analysis based on convolutional neural networks (CNNs) and commonly available patient data (age, sex and anatomical site of the lesion) in a binary melanoma/nevus classification task could increase the performance compared with CNNs alone. - Methods - We used 431 WSIs from two different laboratories and analysed the performance of classifiers that used the image or patient data individually or three common fusion techniques. Furthermore, we tested a naive combination of patient data and an image classifier: for cases interpreted as ‘uncertain’ (CNN output score <0.7), the decision of the CNN was replaced by the decision of the patient data classifier. - Results - The CNN on its own achieved the best performance (mean ± standard deviation of five individual runs) with AUROC of 92.30% ± 0.23% and balanced accuracy of 83.17% ± 0.38%. While the classification performance was not significantly improved in general by any of the tested fusions, naive strategy of replacing the image classifier with the patient data classifier on slides with low output scores improved balanced accuracy to 86.72% ± 0.36%. - Conclusion - In most cases, the CNN on its own was so accurate that patient data integration did not provide any benefit. However, incorporating patient data for lesions that were classified by the CNN with low ‘confidence’ improved balanced accuracy. |
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| DOI: | doi:10.1016/j.ejca.2021.02.032 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejca.2021.02.032 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0959804921001404 |
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| | DOI: https://doi.org/10.1016/j.ejca.2021.02.032 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Convolutional neural networks |
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| | Data fusion |
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| | Histologic whole slide images |
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| | Patient data |
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| | Skin cancer classification |
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| K10plus-PPN: | 1762744287 |
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| Verknüpfungen: | → Zeitschrift |
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Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification / Höhn, Julia [VerfasserIn]; 7 April 2021 (Online-Ressource)
