Histology core-specific evaluation of the European Society of Urogenital Radiology (ESUR) standardised scoring system of multiparametric magnetic resonance imaging (mpMRI) of the prostate

• Verfasst von: Kuru, Timur Hasan [VerfasserIn]
• Verfasst von: Röthke, Matthias C. [VerfasserIn]
• Verfasst von: Rieker, Philip [VerfasserIn]
• Verfasst von: Roth, Wilfried [VerfasserIn]
• Verfasst von: Fenchel, Michael Christian [VerfasserIn]
• Verfasst von: Hohenfellner, Markus [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Hadaschik, Boris [VerfasserIn]
• Titel: Histology core-specific evaluation of the European Society of Urogenital Radiology (ESUR) standardised scoring system of multiparametric magnetic resonance imaging (mpMRI) of the prostate
• Verf.angabe: Timur H. Kuru, Matthias C. Roethke, Philip Rieker, Wilfried Roth, Michael Fenchel, Markus Hohenfellner, Heinz-Peter Schlemmer and Boris A. Hadaschik
• E-Jahr: 2013
• Jahr: 23 May 2013
• Umfang: 8 S.
• Teil: volume:112
• Teil: year:2013
• Teil: number:8
• Teil: month:12
• Teil: pages:1080-1087
• Teil: extent:8
• Fussnoten: Gesehen am 14.07.2021
• Titel Quelle: Enthalten in: BJU international
• Ort Quelle: Oxford : Wiley-Blackwell, 1999
• Jahr Quelle: 2013
• Band/Heft Quelle: 112(2013), 8 vom: Dez., Seite 1080-1087
• ISSN Quelle: 1464-410X
• DOI: doi:10.1111/bju.12259
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: biopsy
• Sach-SW: hybrid imaging
• Sach-SW: mpMRI
• Sach-SW: PIRADS-score
• Sach-SW: prostate
• K10plus-PPN: 1762856670

Abstract

Objectives To evaluate the Prostate Imaging Reporting and Data System (PIRADS) in multiparametric magnetic resonance imaging (mpMRI) based on single cores and single-core histology. To calculate positive (PPV) and negative predictive values (NPV) of different modalities of mpMRI. Patients and Methods We performed MRI-targeted transrectal ultrasound-guided perineal prostate biopsies on 50 patients (mean age 66 years, mean PSA level of 9.9 ng/mL) with suspicion of prostate cancer. The biopsy trajectories of every core taken were documented in three dimensions (3D) in a 3D-prostate model. Every core was evaluated separately for prostate cancer and the performed biopsy trajectories were projected on mpMRI images. PIRADS scores of 1177 cores were then assessed by a histology ‘blinded’ uro-radiologist in T2-weighted (T2W), dynamic contrast-enhanced (DCE), diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS). Results The PIRADS score was significantly higher in cores positive for cancer than in negative cores. There was a significant correlation between the PIRADS score and histopathology for every modality. Receiver operating characteristic (ROC) analysis showed excellent specificity for T2W (90% peripheral zone/97% transition zone) and DWI (98%/97%) images regardless of the prostate region observed. These numbers decreased for DCE (80%/93%) and MRS (76%/83%). All modalities had NPVs of 99%, if a PIRADS score threshold of 2 (for T2W, DCE, and MRS) or 3 (for DWI) was used. However, PPVs were low. Conclusions Our results show that PIRADS scoring is feasible for clinical routine and allows standardised reporting. PIRADS can be used as a decision-support system for targeting of suspicious lesions. mpMRI has a high NPV for prostate cancer and, thus, might be a valuable tool in the initial diagnostic evaluation.