TRPM4 keeps up the pace

• Verfasst von: Ambroziak, Wojciech [VerfasserIn]
• Verfasst von: Siemens, Jan [VerfasserIn]
• Titel: TRPM4 keeps up the pace
• Verf.angabe: Wojciech Ambroziak, Jan Siemens
• E-Jahr: 2021
• Jahr: 30 March 2021
• Umfang: 3 S.
• Teil: volume:96
• Teil: year:2021
• Teil: month:06
• Teil: elocationid:102401
• Teil: pages:1-3
• Teil: extent:3
• Fussnoten: Gesehen am 14.07.2021
• Titel Quelle: Enthalten in: Cell calcium
• Ort Quelle: Edinburgh [u.a.] : Churchill Livingstone, 1980
• Jahr Quelle: 2021
• Band/Heft Quelle: 96(2021) vom: Juni, Artikel-ID 102401, Seite 1-3
• ISSN Quelle: 1532-1991
• DOI: doi:10.1016/j.ceca.2021.102401
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: action potential
• Sach-SW: autonomous firing
• Sach-SW: pacemaking
• Sach-SW: Trp ion channel
• K10plus-PPN: 1762887711

Abstract

The study by Li et al., provides a detailed pharmacological characterization of the ionic mechanisms that underlie rhythmic activity of retrotrapezoid nucleus neurons that control breathing. Specifically, the authors demonstrate a role of the transient receptor potential melastatin 4 (TRPM4) ion channel in the generation of subthreshold excitatory oscillations. Additionally, they propose that the ion channel contributes to tonic action potential (AP) firing - referred to as “pacemaking” - of these brainstem neurons with relevance for respiratory breathing and homeostasis in vivo.