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Verfasst von:Riedel, Fabian [VerfasserIn]   i
 Hoffmann, Ann Sophie [VerfasserIn]   i
 Moderow, Mareike [VerfasserIn]   i
 Feißt, Manuel [VerfasserIn]   i
 Heublein, Sabine [VerfasserIn]   i
 Deutsch, Thomas M. [VerfasserIn]   i
 Schäfgen, Benedikt [VerfasserIn]   i
 Golatta, Michael [VerfasserIn]   i
 Domschke, Christoph [VerfasserIn]   i
 Wallwiener, Markus [VerfasserIn]   i
 Heil, Jörg [VerfasserIn]   i
 Hennigs, André [VerfasserIn]   i
Titel:Do hospital type or caseload make a difference in chemotherapy treatment patterns for early breast cancer?
Titelzusatz:results from 104 German institutions, 2008-2017
Verf.angabe:Fabian Riedel, Ann Sophie Hoffmann, Mareike Moderow, Manuel Feisst, Sabine Heublein, Thomas Maximilian Deutsch, Benedikt Schäfgen, Michael Golatta, Christoph Domschke, Markus Wallwiener, Jörg Heil, André Hennigs
E-Jahr:2021
Jahr:23 April 2021
Umfang:9 S.
Fussnoten:Gesehen am 14.07.2021
Titel Quelle:Enthalten in: The breast
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1992
Jahr Quelle:2021
Band/Heft Quelle:58(2021) vom: Aug., Seite 63-71
ISSN Quelle:1532-3080
Abstract:Background - Over the past decade, chemotherapy has been used more selectively in early breast cancer (EBC) due to better risk stratification. Neoadjuvant chemotherapy (NACT) has evolved to the primary treatment option. The type and size of hospitals is known to have a substantial influence on the kinds of treatment they provide, and therefore on patient outcomes (e.g. rates for pathological complete response, pCR), but it is not yet known how this has affected delivery of chemotherapy for EBC in Germany. - Methods - This study analyzed chemotherapy use and pCR rates after NACT for EBC patients treated at 104 German institutions 2008-2017. Institutions were separated into associated hospital type (university hospital; teaching hospital; community hospital) and annual caseload (≤100; 101-250; >250 cases/year). - Results - Overall, 124,084 patients were included, of whom 11.6% were treated at university hospitals, 63.1% at teaching hospitals, and 25.3% at community hospitals. In total, 46,274 (37.3%) received chemotherapy, of whom 44,765 had information available about systemic treatment and surgery. From 2008 to 2017, chemotherapy use declined from 48.3% to 36.4% for university hospitals, from 40.7% to 30.3% for teaching hospitals, and from 42.4% to 33.7% for community hospitals. Furthermore, the proportion of NACT increased the most in university hospitals (from 32.0% to 68.1%); whereas, the rate of pCR (defined as ypT0 ypN0) increased irrespective of institutional type. Analyses regarding annual caseload did not show any differences. - Conclusions - The results from this large, nationwide cohort reflect a more selective use of chemotherapy in Germany, irrespective of institutional type or case load.
DOI:doi:10.1016/j.breast.2021.04.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.breast.2021.04.006
 Volltext: https://www.sciencedirect.com/science/article/pii/S0960977621003581
 DOI: https://doi.org/10.1016/j.breast.2021.04.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Case load
 Early breast cancer
 Hospital type
 Neoadjuvant chemotherapy
 Pathological complete response
K10plus-PPN:1762909626
Verknüpfungen:→ Zeitschrift

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