| |  Online-Ressource |
|---|
| Verfasst von: | Sievers, Philipp [VerfasserIn]  |
|---|
| | Sill, Martin [VerfasserIn] |
|---|
| | Schrimpf, Daniel [VerfasserIn] |
|---|
| | Stichel, Damian [VerfasserIn] |
|---|
| | Reuss, David [VerfasserIn] |
|---|
| | Sturm, Dominik [VerfasserIn] |
|---|
| | Hench, Jürgen [VerfasserIn] |
|---|
| | Frank, Stephan [VerfasserIn] |
|---|
| | Krskova, Lenka [VerfasserIn] |
|---|
| | Vicha, Ales [VerfasserIn] |
|---|
| | Zapotocky, Michal [VerfasserIn] |
|---|
| | Bison, Brigitte [VerfasserIn] |
|---|
| | Castel, David [VerfasserIn] |
|---|
| | Grill, Jacques [VerfasserIn] |
|---|
| | Debily, Marie-Anne [VerfasserIn] |
|---|
| | Harter, Patrick N [VerfasserIn] |
|---|
| | Snuderl, Matija [VerfasserIn] |
|---|
| | Kramm, Christof M [VerfasserIn] |
|---|
| | Reifenberger, Guido [VerfasserIn] |
|---|
| | Korshunov, Andrey [VerfasserIn] |
|---|
| | Jabado, Nada [VerfasserIn] |
|---|
| | Wesseling, Pieter [VerfasserIn] |
|---|
| | Wick, Wolfgang [VerfasserIn] |
|---|
| | Solomon, David A [VerfasserIn] |
|---|
| | Perry, Arie [VerfasserIn] |
|---|
| | Jacques, Thomas S [VerfasserIn] |
|---|
| | Jones, Chris [VerfasserIn] |
|---|
| | Witt, Olaf [VerfasserIn] |
|---|
| | Pfister, Stefan [VerfasserIn] |
|---|
| | Deimling, Andreas von [VerfasserIn] |
|---|
| | Jones, David T. W. [VerfasserIn] |
|---|
| | Sahm, Felix [VerfasserIn] |
|---|
| Titel: | A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR |
|---|
| Verf.angabe: | Philipp Sievers, Martin Sill, Daniel Schrimpf, Damian Stichel, David E. Reuss, Dominik Sturm, Jürgen Hench, Stephan Frank, Lenka Krskova, Ales Vicha, Michal Zapotocky, Brigitte Bison, David Castel, Jacques Grill, Marie-Anne Debily, Patrick N. Harter, Matija Snuderl, Christof M. Kramm, Guido Reifenberger, Andrey Korshunov, Nada Jabado, Pieter Wesseling, Wolfgang Wick, David A. Solomon, Arie Perry, Thomas S. Jacques, Chris Jones, Olaf Witt, Stefan M. Pfister, Andreas von Deimling, David T.W. Jones, and Felix Sahm |
|---|
| Jahr: | 2021 |
|---|
| Umfang: | 10 S. |
|---|
| Fussnoten: | Advance access date 1 November 2020 ; Gesehen am 15.07.2021 |
|---|
| Titel Quelle: | Enthalten in: Neuro-Oncology |
|---|
| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
|---|
| Jahr Quelle: | 2021 |
|---|
| Band/Heft Quelle: | 23(2021), 1, Seite 34-43 |
|---|
| ISSN Quelle: | 1523-5866 |
|---|
| Abstract: | Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the epidermal growth factor receptor gene (EGFR) have recently been identified in a distinct subset of pediatric-type bithalamic gliomas with a unique DNA methylation pattern.Here, we investigated an epigenetically homogeneous cohort of malignant gliomas (n = 58) distinct from other subtypes and enriched for pediatric cases and thalamic location, in comparison with this recently identified subtype of pediatric bithalamic gliomas.EGFR gene amplification was detected in 16/58 (27%) tumors, and missense mutations or small in-frame insertions in EGFR were found in 20/30 tumors with available sequencing data (67%; 5 of them co-occurring with EGFR amplification). Additionally, 8 of the 30 tumors (27%) harbored an H3.1 or H3.3 K27M mutation (6 of them with a concomitant EGFR alteration). All tumors tested showed loss of H3K27me3 staining, with evidence of overexpression of the EZH inhibitory protein (EZHIP) in the H3 wildtype cases. Although some tumors indeed showed a bithalamic growth pattern, a significant proportion of tumors occurred in the unilateral thalamus or in other (predominantly midline) locations.Our findings present a distinct molecular class of pediatric-type malignant gliomas largely overlapping with the recently reported bithalamic gliomas characterized by EGFR alteration, but additionally showing a broader spectrum of EGFR alterations and tumor localization. Global H3K27me3 loss in this group appears to be mediated by either H3 K27 mutation or EZHIP overexpression. EGFR inhibition may represent a potential therapeutic strategy in these highly aggressive gliomas. |
|---|
| DOI: | doi:10.1093/neuonc/noaa251 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1093/neuonc/noaa251 |
|---|
| | Volltext: https://academic.oup.com/neuro-oncology/article/23/1/34/5948536 |
|---|
| | DOI: https://doi.org/10.1093/neuonc/noaa251 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1762945835 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬A¬ subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR / Sievers, Philipp [VerfasserIn]; 2021 (Online-Ressource)
