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Status: Bibliographieeintrag

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Verfasst von:Schaier, Matthias [VerfasserIn]   i
 Gottschalk, Claudius [VerfasserIn]   i
 Kälble, Florian [VerfasserIn]   i
 Uhlmann, Lorenz [VerfasserIn]   i
 Eckstein, Volker [VerfasserIn]   i
 Müller-Tidow, Carsten [VerfasserIn]   i
 Meuer, Stefan [VerfasserIn]   i
 Mahnke, Karsten [VerfasserIn]   i
 Lorenz, Hanns-Martin [VerfasserIn]   i
 Zeier, Martin [VerfasserIn]   i
 Steinborn-Kröhl, Andrea [VerfasserIn]   i
Titel:The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation
Verf.angabe:M. Schaier, C. Gottschalk, F. Kälble, L. Uhlmann, V. Eckstein, C. Müller-Tidow, S. Meuer, K. Mahnke, H.-M. Lorenz, M. Zeier, A. Steinborn
E-Jahr:2021
Jahr:09/04/2021
Umfang:10 S.
Fussnoten:Im Titel ist "+" hochgestellt ; Gesehen am 15.07.2021
Titel Quelle:Enthalten in: Clinical and experimental rheumatology
Ort Quelle:Pisa : [Verlag nicht ermittelbar], 1999
Jahr Quelle:2021
Band/Heft Quelle:39(2021), 2, Seite 279-288
ISSN Quelle:1593-098X
Abstract:OBJECTIVES: An imbalance between CD4+-regulatory T-cells (Tregs) and CD4+-responder T-cells (Tresps) correlates with active disease flares in systemic lupus erythematosus (SLE) patients. Both cell subsets consist of highly proliferating Tregs/Tresps expressing inducible T-cell co-stimulatory molecule (ICOS) and less proliferating ICOS--Tregs/Tresps. METHODS: Six-colour-flow-cytometric analysis was used to examine the effect of ICOS+- and ICOS--Treg/Tresp cell differentiation on the composition of the total CD4+-T-helper cell pool with ICOS+- and ICOS--Tregs/Tresps. Functionality of Tregs was examined using suppression assays. RESULTS: In 83 healthy volunteers, the ratio of ICOS+-Tregs/ICOS+-Tresps increased significantly with age, while that of ICOS--Tregs/ICOS--Tresps did not change. In 86 SLE patients (SLEDAI <7), disease activity was associated with an age-independently increased ratio of both ICOS+-Tregs/ICOS+-Tresps and ICOS--Tregs/ICOS--Tresps. In these patients, the functional activity of ICOS+-Tregs, but not of ICOS--Tregs, was preserved. In 13 markedly active disease patients (SLEDAI >7), the percentage of both ICOS+-Tregs and ICOS+-Tresps, was strongly increased within total CD4+-T-helper cells. However, the increased ratio of ICOS+-Tregs/ICOS+-Tresps was not maintained in these patients, due to terminal differentiation and accumulation of naïve cells within total ICOS+-Tregs. Despite increased differentiation of both ICOS--Tregs and ICOS--Tresps, the percentage of ICOS--Tregs increased within CD4+-T-helper cells, while that of ICOS--Tresps decreased, resulting in a significantly increased ratio of ICOS--Tregs/ICOS--Tresps independent of age. CONCLUSIONS: Our data reveal a crucial role of Treg immune senescence for the occurrence of disease flares in SLE patients, with ICOS+-Treg cells being most affected.
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Volltext: https://pubmed.ncbi.nlm.nih.gov/32573411/
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CD4-Positive T-Lymphocytes
 Cell Differentiation
 Humans
 Lupus Erythematosus, Systemic
 Lymphocyte Activation
 T-Lymphocyte Subsets
 T-Lymphocytes, Regulatory
K10plus-PPN:1762956756
Verknüpfungen:→ Zeitschrift

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