| Online-Ressource |
Verfasst von: | Schaier, Matthias [VerfasserIn]  |
| Gottschalk, Claudius [VerfasserIn]  |
| Kälble, Florian [VerfasserIn]  |
| Uhlmann, Lorenz [VerfasserIn]  |
| Eckstein, Volker [VerfasserIn]  |
| Müller-Tidow, Carsten [VerfasserIn]  |
| Meuer, Stefan [VerfasserIn]  |
| Mahnke, Karsten [VerfasserIn]  |
| Lorenz, Hanns-Martin [VerfasserIn]  |
| Zeier, Martin [VerfasserIn]  |
| Steinborn-Kröhl, Andrea [VerfasserIn]  |
Titel: | The onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation |
Verf.angabe: | M. Schaier, C. Gottschalk, F. Kälble, L. Uhlmann, V. Eckstein, C. Müller-Tidow, S. Meuer, K. Mahnke, H.-M. Lorenz, M. Zeier, A. Steinborn |
E-Jahr: | 2021 |
Jahr: | 09/04/2021 |
Umfang: | 10 S. |
Fussnoten: | Im Titel ist "+" hochgestellt ; Gesehen am 15.07.2021 |
Titel Quelle: | Enthalten in: Clinical and experimental rheumatology |
Ort Quelle: | Pisa : [Verlag nicht ermittelbar], 1999 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 39(2021), 2, Seite 279-288 |
ISSN Quelle: | 1593-098X |
Abstract: | OBJECTIVES: An imbalance between CD4+-regulatory T-cells (Tregs) and CD4+-responder T-cells (Tresps) correlates with active disease flares in systemic lupus erythematosus (SLE) patients. Both cell subsets consist of highly proliferating Tregs/Tresps expressing inducible T-cell co-stimulatory molecule (ICOS) and less proliferating ICOS--Tregs/Tresps. METHODS: Six-colour-flow-cytometric analysis was used to examine the effect of ICOS+- and ICOS--Treg/Tresp cell differentiation on the composition of the total CD4+-T-helper cell pool with ICOS+- and ICOS--Tregs/Tresps. Functionality of Tregs was examined using suppression assays. RESULTS: In 83 healthy volunteers, the ratio of ICOS+-Tregs/ICOS+-Tresps increased significantly with age, while that of ICOS--Tregs/ICOS--Tresps did not change. In 86 SLE patients (SLEDAI <7), disease activity was associated with an age-independently increased ratio of both ICOS+-Tregs/ICOS+-Tresps and ICOS--Tregs/ICOS--Tresps. In these patients, the functional activity of ICOS+-Tregs, but not of ICOS--Tregs, was preserved. In 13 markedly active disease patients (SLEDAI >7), the percentage of both ICOS+-Tregs and ICOS+-Tresps, was strongly increased within total CD4+-T-helper cells. However, the increased ratio of ICOS+-Tregs/ICOS+-Tresps was not maintained in these patients, due to terminal differentiation and accumulation of naïve cells within total ICOS+-Tregs. Despite increased differentiation of both ICOS--Tregs and ICOS--Tresps, the percentage of ICOS--Tregs increased within CD4+-T-helper cells, while that of ICOS--Tresps decreased, resulting in a significantly increased ratio of ICOS--Tregs/ICOS--Tresps independent of age. CONCLUSIONS: Our data reveal a crucial role of Treg immune senescence for the occurrence of disease flares in SLE patients, with ICOS+-Treg cells being most affected. |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://pubmed.ncbi.nlm.nih.gov/32573411/ |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | CD4-Positive T-Lymphocytes |
| Cell Differentiation |
| Humans |
| Lupus Erythematosus, Systemic |
| Lymphocyte Activation |
| T-Lymphocyte Subsets |
| T-Lymphocytes, Regulatory |
K10plus-PPN: | 1762956756 |
Verknüpfungen: | → Zeitschrift |
¬The¬ onset of active disease in systemic lupus erythematosus patients is characterised by excessive regulatory CD4+-T-cell differentiation / Schaier, Matthias [VerfasserIn]; 09/04/2021 (Online-Ressource)