Zirconium hydrazinediido complexes derived from cyclic hydrazines and their role in the catalytic synthesis of 1,7-annulated indoles

• Verfasst von: Scholl, Solveig A. [VerfasserIn]
• Verfasst von: Wadepohl, Hubert [VerfasserIn]
• Verfasst von: Gade, Lutz H. [VerfasserIn]
• Titel: Zirconium hydrazinediido complexes derived from cyclic hydrazines and their role in the catalytic synthesis of 1,7-annulated indoles
• Verf.angabe: Solveig A. Scholl, Hubert Wadepohl, and Lutz H. Gade
• E-Jahr: 2013
• Jahr: January 27, 2013
• Umfang: 4 S.
• Teil: volume:32
• Teil: year:2013
• Teil: number:3
• Teil: pages:937-940
• Teil: extent:4
• Fussnoten: Gesehen am 15.07.2021
• Titel Quelle: Enthalten in: Organometallics
• Ort Quelle: Washington, DC : ACS Publ., 1982
• Jahr Quelle: 2013
• Band/Heft Quelle: 32(2013), 3, Seite 937-940
• ISSN Quelle: 1520-6041
• DOI: doi:10.1021/om301235d
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1762975955

Abstract

Reaction of cyclic 1,1′-disubstituted hydrazines with the bis(dimethylamido)zirconium complex [Zr{(NXyl)2Npy} (NMe2)2] (1) in the presence of dmap yielded the hexacoordinate zirconium hydrazinediido complexes [Zr{(NXyl)2Npy}(═NNC9H10)(dmap)2] (2) and [Zr{(NXyl)2Npy}(═NNC12H8)(dmap)2] (3). Hydrazinediides are thought to be key intermediates in the zirconium-catalyzed reaction of cyclic 1,1′-disubstituted hydrazines and disubstituted alkynes to yield 1,7-annulated indoles. Their basic structural motif is found in 5-HT3 receptor antagonists such as Cilansetron.