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| Verfasst von: | Sommerer, Claudia [VerfasserIn]  |
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| | Brunet, Mercè [VerfasserIn] |
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| | Budde, Klemens [VerfasserIn] |
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| | Millán, Olga [VerfasserIn] |
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| | Guirado Perich, Lluis [VerfasserIn] |
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| | Glander, Petra [VerfasserIn] |
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| | Meuer, Stefan [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| Titel: | Monitoring of gene expression in tacrolimus-treated de novo renal allograft recipients facilitates individualized immunosuppression |
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| Titelzusatz: | results of the IMAGEN study |
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| Verf.angabe: | Claudia Sommerer, Mercè Brunet, Klemens Budde, Olga Millán, Lluis Guirado Perich, Petra Glander, Stefan Meuer, Martin Zeier, Thomas Giese |
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| E-Jahr: | 2021 |
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| Jahr: | 23 February 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | First published: 23 February 2021 ; Gesehen am 15.07.2021 |
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| Titel Quelle: | Enthalten in: British journal of clinical pharmacology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1974 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 87(2021), Seite 1-12 |
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| ISSN Quelle: | 1365-2125 |
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| Abstract: | AIMS: Calcineurin inhibitors (CNI) have a small therapeutic window, and drug monitoring is required. Pharmacokinetic monitoring does not correlate sufficiently with clinical outcome. Therefore, the expression of nuclear factor of activated T cells (NFAT)-regulated genes in the peripheral blood has been suggested as a potentially useful immune monitoring tool to optimize CNI therapy. NFAT-regulated gene expression (RGE) was evaluated in renal allograft recipients as predictive biomarker to detect patients at risk of acute rejection or infections. METHODS: NFAT-RGE (interleukin-2, interferon-γ, granular-macrophage colony-stimulating factor) was evaluated by quantitative real-time polymerase chain reaction in whole blood samples at day 7, day 14, month 1, 3, and 6 after transplantation in 64 de novo renal allograft recipients from 3 European centres. Immunosuppression consisted of tacrolimus (Tac), mycophenolic acid, and corticosteroids. RESULTS: Tac concentrations (C0 and C1.5) correlated inversely with NFAT-RGE (P < .01). NFAT-RGE showed a high interindividual variability (1-61%). Patients with high residual gene expression (NFAT-RGE ≥30%) were at the increased risk of acute rejection in the following months (35 vs. 5%, P = .02), whereas patients with low residual gene expression (NFAT-RGE <30%) showed a higher incidence of viral complications, especially cytomegalovirus and BK virus replication (52.5 vs. 10%, P = .01). CONCLUSIONS: NFAT-RGE was confirmed as a potential noninvasive early predictive biomarker in the immediate post-transplant period to detect patients at risk of acute rejection and infectious complications in Tac-treated renal allograft recipients. Monitoring of NFAT-RGE may provide additional useful information for physicians to achieve individualized Tac treatment. |
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| DOI: | doi:10.1111/bcp.14794 |
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| URL: | kostenfrei: Volltext: https://doi.org/https://doi.org/10.1111/bcp.14794 |
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| | kostenfrei: Volltext: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bcp.14794 |
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| | DOI: https://doi.org/10.1111/bcp.14794 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | cytomegalovirus |
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| | pharmacodynamics |
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| | pharmacokinetics |
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| | rejection |
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| | renal transplantation |
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| | tacrolimus |
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| K10plus-PPN: | 1762984210 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Monitoring of gene expression in tacrolimus-treated de novo renal allograft recipients facilitates individualized immunosuppression / Sommerer, Claudia [VerfasserIn]; 23 February 2021 (Online-Ressource)
