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| Verfasst von: | Schmitz, Norbert [VerfasserIn]  |
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| | Truemper, Lorenz H. [VerfasserIn] |
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| | Bouabdallah, Krimo [VerfasserIn] |
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| | Ziepert, Marita [VerfasserIn] |
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| | Leclerc, Mathieu [VerfasserIn] |
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| | Cartron, Guillaume [VerfasserIn] |
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| | Jaccard, Arnaud [VerfasserIn] |
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| | Reimer, Peter [VerfasserIn] |
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| | Wagner-Drouet, Eva [VerfasserIn] |
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| | Wilhelm, Martin [VerfasserIn] |
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| | Sanhes, Laurence [VerfasserIn] |
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| | Lamy, Thierry [VerfasserIn] |
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| | De Leval, Laurence [VerfasserIn] |
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| | Rosenwald, Andreas [VerfasserIn] |
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| | Roussel, Murielle [VerfasserIn] |
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| | Kroschinsky, Frank P. [VerfasserIn] |
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| | Lindemann, Walter Walter [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Viardot, Andreas [VerfasserIn] |
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| | Milpied, Noel J. [VerfasserIn] |
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| | Gisselbrecht, Christian [VerfasserIn] |
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| | Wulf, Gerald G. [VerfasserIn] |
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| | Gyan, Emmanuel [VerfasserIn] |
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| | Gaulard, Philippe [VerfasserIn] |
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| | Bay, Jacques-Olivier [VerfasserIn] |
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| | Glaß, Bertram [VerfasserIn] |
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| | Poeschel, Viola [VerfasserIn] |
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| | Damaj, Gandhi [VerfasserIn] |
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| | Sibon, David [VerfasserIn] |
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| | Delmer, Alain Jacques [VerfasserIn] |
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| | Bilger, Karin [VerfasserIn] |
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| | Banos, Anne [VerfasserIn] |
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| | Haenel, Mathias [VerfasserIn] |
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| | Dreyling, Martin [VerfasserIn] |
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| | Metzner, Bernd [VerfasserIn] |
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| | Keller, Ulrich [VerfasserIn] |
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| | Braulke, Friederike [VerfasserIn] |
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| | Friedrichs, Birte [VerfasserIn] |
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| | Nickelsen, Maike [VerfasserIn] |
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| | Altmann, Bettina [VerfasserIn] |
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| | Tournilhac, Olivier [VerfasserIn] |
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| Titel: | A randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL |
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| Verf.angabe: | Norbert Schmitz, Lorenz Truemper, Krimo Bouabdallah, Marita Ziepert, Mathieu Leclerc, Guillaume Cartron, Arnaud Jaccard, Peter Reimer, Eva Wagner, Martin Wilhelm, Laurence Sanhes, Thierry Lamy, Laurence de Leval, Andreas Rosenwald, Muriel Roussel, Frank Kroschinsky, Walter Lindemann, Peter Dreger, Andreas Viardot, Noël Milpied, Christian Gisselbrecht, Gerald Wulf, Emmanuel Gyan, Philippe Gaulard, Jacques Olivier Bay, Bertram Glass, Viola Poeschel, Gandhi Damaj, David Sibon, Alain Delmer, Karin Bilger, Anne Banos, Mathias Haenel, Martin Dreyling, Bernd Metzner, Ulrich Keller, Friederike Braulke, Birte Friedrichs, Maike Nickelsen, Bettina Altmann, Olivier Tournilhac for the French Lymphoma Study Association (LYSA) and the German Lymphoma Alliance (GLA) |
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| Jahr: | 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Online first: 8 January 2021 ; Gesehen am 16.07.2021 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 137(2021), 19 vom: 13. Mai, Seite 2646-2656 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | First-line therapy for younger patients with peripheral T-cell non-Hodgkin lymphoma (T-NHL) consists of 6 courses of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without etoposide (CHOEP), consolidated by high-dose therapy and autologous stem cell transplantation (auto-SCT). We hypothesized that allogeneic stem cell transplantation (allo-SCT) could improve outcomes. 104 patients with peripheral T-cell non-Hodgkin lymphoma, except ALK+ anaplastic large cell lymphoma, 18 to 60 years, all stages, and all age adjusted International Prognostic Index scores, except 0 and stage I, were randomized to 4 cycles of CHOEP and 1 cycle of dexamethasone, cytosine-arabinoside, and platinum (DHAP) followed by high-dose therapy and auto-SCT or myeloablative conditioning and allo-SCT. The primary end point was event-free survival (EFS) at 3 years. After a median follow-up of 42 months, the 3-year EFS after allo-SCT was 43%, as compared with 38% after auto-SCT. Overall survival at 3 years was 57% vs 70% after allo- or auto-SCT, without significant differences between treatment arms. None of the 21 responding patients proceeding to allo-SCT relapsed, as opposed to 13 of 36 patients (36%) proceeding to auto-SCT. Eight of 26 patients (31%) and none of 41 patients died of transplant-related toxicity after allo- and auto-SCT, respectively. The strong graft-versus-lymphoma effect after allo-SCT was counterbalanced by transplant-related mortality. This trial is registered at www.clinicaltrials.gov as #NCT00984412. |
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| DOI: | doi:10.1182/blood.2020008825 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood.2020008825 |
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| | DOI: https://doi.org/10.1182/blood.2020008825 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1755593104 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ randomized phase 3 trial of autologous vs allogeneic transplantation as part of first-line therapy in poor-risk peripheral T-NHL / Schmitz, Norbert [VerfasserIn]; 2021 (Online-Ressource)
