Crossing the blood-brain barrier

• Verfasst von: Mahringer, Anne [VerfasserIn]
• Verfasst von: Puris, Elena [VerfasserIn]
• Verfasst von: Fricker, Gert [VerfasserIn]
• Titel: Crossing the blood-brain barrier
• Titelzusatz: a review on drug delivery strategies using colloidal carrier systems
• Verf.angabe: Anne Mahringer, Elena Puris, Gert Fricker
• E-Jahr: 2021
• Jahr: 20 April 2021
• Umfang: 9 S.
• Teil: volume:147
• Teil: year:2021
• Teil: elocationid:105017
• Teil: extent:9
• Fussnoten: Gesehen am 20.07.2021
• Titel Quelle: Enthalten in: Neurochemistry international
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1980
• Jahr Quelle: 2021
• Band/Heft Quelle: 147(2021), Artikel-ID 105017
• ISSN Quelle: 1872-9754
• DOI: doi:10.1016/j.neuint.2021.105017
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Blood-brain barrier
• Sach-SW: Liposome
• Sach-SW: Nanoparticle
• Sach-SW: Receptor
• K10plus-PPN: 1763718980

Abstract

The blood-brain barrier represents the major challenge for delivering drugs to the central nervous system (CNS). It separates the blood circulation from the brain tissue, thereby protecting the CNS and maintaining its ion homeostasis. Unfortunately, most drugs are not able to cross this barrier in vivo despite promising in vitro results. One approach to solve this problem is the delivery of drugs via surface modified nanocarrier systems. This review will give an overview on currently tested systems, mainly liposomes and solid nanoparticles and inform about new developments.