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| Verfasst von: | Tollens, Fabian [VerfasserIn]  |
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| | Baltzer, Pascal Andreas Thomas [VerfasserIn] |
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| | Dietzel, Matthias [VerfasserIn] |
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| | Rübenthaler, Johannes [VerfasserIn] |
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| | Froelich, Matthias F. [VerfasserIn] |
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| | Kaiser, Clemens G. [VerfasserIn] |
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| Titel: | Cost-effectiveness of digital breast tomosynthesis vs. abbreviated breast MRI for screening women with intermediate risk of breast cancer |
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| Titelzusatz: | how low-cost must MRI be? |
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| Verf.angabe: | Fabian Tollens, Pascal A.T. Baltzer, Matthias Dietzel, Johannes Rübenthaler, Matthias F. Froelich and Clemens G. Kaiser |
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| E-Jahr: | 2021 |
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| Jahr: | 12 March 2021 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 20.07.2021 |
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| Weitere Titel: | Titel des Special issues: Novel insights into biology and cancers |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 6, special issue, Artikel-ID 1241, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Background: Digital breast tomosynthesis (DBT) and abbreviated breast MRI (AB-MRI) offer superior diagnostic performance compared to conventional mammography in screening women with intermediate risk of breast cancer due to dense breast tissue. The aim of this model-based economic evaluation was to analyze whether AB-MRI is cost-effective in this cohort compared to DBT. Methods: Decision analysis and Markov simulations were used to model the cumulative costs and quality-adjusted life-years (QALYs) over a time horizon of 30 years. Model input parameters were adopted from recent literature. Deterministic and probabilistic sensitivity analyses were applied to test the stability of the model. Results: In the base-case scenario, the costs of an AB-MRI examination were defined to equal the costs of a full protocol acquisition. Two-yearly screening of women with dense breasts resulted in cumulative discounted costs of $8798 and $9505 for DBT and AB-MRI, and cumulative discounted effects of 19.23 and 19.27 QALYs, respectively, with an incremental cost-effectiveness ratio of $20,807 per QALY gained in the base-case scenario. By reducing the cost of an AB-MRI examination below a threshold of $241 in sensitivity analyses, AB-MRI would become cost-saving compared to DBT. Conclusion: In comparison to DBT, AB-MRI can be considered cost-effective up to a price per examination of $593 in screening patients at intermediate risk of breast cancer. |
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| DOI: | doi:10.3390/cancers13061241 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers13061241 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/6/1241 |
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| | DOI: https://doi.org/10.3390/cancers13061241 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AB-MRI |
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| | breast cancer |
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| | cost-effectiveness analyses |
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| | cost-effectiveness threshold |
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| | intermediate-risk screening |
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| | MR-Mammography |
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| | tomosynthesis |
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| K10plus-PPN: | 1763732983 |
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| Verknüpfungen: | → Zeitschrift |
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Cost-effectiveness of digital breast tomosynthesis vs. abbreviated breast MRI for screening women with intermediate risk of breast cancer / Tollens, Fabian [VerfasserIn]; 12 March 2021 (Online-Ressource)
