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Status: Bibliographieeintrag

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Verfasst von:Tapking, Christian [VerfasserIn]   i
 Hernekamp, Jochen-Frederick [VerfasserIn]   i
 Horter, Johannes [VerfasserIn]   i
 Kneser, Ulrich [VerfasserIn]   i
 Haug, Valentin [VerfasserIn]   i
 Vogelpohl, Johanna [VerfasserIn]   i
 Schulte, Megahn [VerfasserIn]   i
 Kremer, Thomas [VerfasserIn]   i
 Hundeshagen, Gabriel [VerfasserIn]   i
Titel:Influence of burn severity on endothelial glycocalyx shedding following thermal trauma
Titelzusatz:a prospective observational study
Verf.angabe:C. Tapking, J.F. Hernekamp, J. Horter, U. Kneser, V. Haug, J. Vogelpohl, M. Schulte, T. Kremer, G. Hundeshagen
Jahr:2021
Umfang:7 S.
Fussnoten:Available online 5 August 2020 ; Gesehen am 26.07.2021
Titel Quelle:Enthalten in: Burns
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1974
Jahr Quelle:2021
Band/Heft Quelle:47(2021), 3 vom: Mai, Seite 621-627
ISSN Quelle:1879-1409
Abstract:Objective - Severe burns cause hypermetabolic and inflammatory responses are treated with significant volume resuscitation. This study aimed to evaluate correlations between glycocalyx metabolites and the burn size as well as certain clinical parameters such as administered fluid volumes. - Study design - Severely burned patients with a total body surface area (TBSA) burned smaller and larger than 20% were included. Clinical parameters including length of stay, mortality, fluid administration and Sequential Organ Failure Assessment (SOFA) score as well as syndecan and heparansulfate, as laboratory parameters for endothelial damage, were obtained. - Results - A total of 39 patients (32 males, 7 females) with a mean age at burn of 45 ± 21 years were included. Syndecan levels decreased and heparansulfate levels increased over time. In both heparansulfate and syndecan, there was no significant difference between burns smaller and larger than 20% TBSA at any time point. Syndecan levels at 24 h after burn correlated significantly with IL-10 levels at admission (R = 0.58 and p < 0.05). There were significant linear correlations of %TBSA and cumulative administration of fluids after 24 h on syndecan levels after 48 h. Correlations between clinical parameters and syndecan or heparansulfate levels over time were not found. - Conclusions - This study shows that even though there are moderate correlations with burn size and administered fluid volume, levels of syndecan and heparansulfate are not predictive for clinical outcomes of burned patients in our cohort. Further studies with higher numbers evaluating the effect of large burns on glycocalyx shedding over a longer period of time are needed. Showing significant glycocalyx shedding in large burn including potentially correlations with clinical outcomes may yield new therapeutic targets.
DOI:doi:10.1016/j.burns.2020.07.021
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.burns.2020.07.021
 Volltext: https://www.sciencedirect.com/science/article/pii/S0305417920304800
 DOI: https://doi.org/10.1016/j.burns.2020.07.021
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Burns
 Fluid resuscitation
 Glycocalyx shedding
 Metabolism
K10plus-PPN:1764369777
Verknüpfungen:→ Zeitschrift

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