| |  Online-Ressource |
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| Verfasst von: | Balta, Emre [VerfasserIn]  |
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| | Wabnitz, Guido H. [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| Titel: | Hijacked immune cells in the tumor microenvironment |
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| Titelzusatz: | molecular mechanisms of immunosuppression and cues to improve T cell-based immunotherapy of solid tumors |
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| Verf.angabe: | Emre Balta, Guido H. Wabnitz and Yvonne Samstag |
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| E-Jahr: | 2021 |
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| Jahr: | 27 May 2021 |
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| Umfang: | 27 S. |
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| Teil: | volume:22 |
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| | year:2021 |
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| | number:11 |
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| | elocationid:5736 |
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| | pages:1-27 |
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| | extent:27 |
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| Fussnoten: | Gesehen am 26.07.2021 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 22(2021), 11, Artikel-ID 5736, Seite 1-27 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The understanding of the tumor microenvironment (TME) has been expanding in recent years in the context of interactions among different cell types, through direct cell-cell communication as well as through soluble factors. It has become evident that the development of a successful antitumor response depends on several TME factors. In this context, the number, type, and subsets of immune cells, as well as the functionality, memory, and exhaustion state of leukocytes are key factors of the TME. Both the presence and functionality of immune cells, in particular T cells, are regulated by cellular and soluble factors of the TME. In this regard, one fundamental reason for failure of antitumor responses is hijacked immune cells, which contribute to the immunosuppressive TME in multiple ways. Specifically, reactive oxygen species (ROS), metabolites, and anti-inflammatory cytokines have central roles in generating an immunosuppressive TME. In this review, we focused on recent developments in the immune cell constituents of the TME, and the micromilieu control of antitumor responses. Furthermore, we highlighted the current challenges of T cell-based immunotherapies and potential future strategies to consider for strengthening their effectiveness. |
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| DOI: | doi:10.3390/ijms22115736 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/ijms22115736 |
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| | Volltext: https://www.mdpi.com/1422-0067/22/11/5736 |
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| | DOI: https://doi.org/10.3390/ijms22115736 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Biomarkers |
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| | cancer immunotherapy |
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| | CAR T cells |
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| | Humans |
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| | Immunologic Surveillance |
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| | Immunomodulation |
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| | immunosuppression |
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| | Immunotherapy |
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| | Lymphocytes, Tumor-Infiltrating |
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| | Neoplasms |
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| | Neutrophil Infiltration |
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| | Reactive Oxygen Species |
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| | ROS |
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| | T-Lymphocyte Subsets |
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| | T-Lymphocytes |
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| | TILs |
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| | TME |
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| | Treatment Outcome |
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| | Tumor Escape |
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| | Tumor Microenvironment |
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| | Tumor-Associated Macrophages |
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| K10plus-PPN: | 1764589092 |
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| Verknüpfungen: | → Zeitschrift |
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Hijacked immune cells in the tumor microenvironment / Balta, Emre [VerfasserIn]; 27 May 2021 (Online-Ressource)
