| |  Online-Ressource |
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| Verfasst von: | Gebert, Johannes [VerfasserIn]  |
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| | Gelincik, Ozkan [VerfasserIn] |
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| | Özcan-Wahlbrink, Mine [VerfasserIn] |
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| | Marshall, Jason D. [VerfasserIn] |
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| | Hernandez Sanchez, Alejandro [VerfasserIn] |
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| | Urban, Katharina [VerfasserIn] |
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| | Long, Mark [VerfasserIn] |
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| | Cortes, Eduardo [VerfasserIn] |
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| | Tosti, Elena [VerfasserIn] |
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| | Katzenmaier, Eva-Maria Katharina [VerfasserIn] |
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| | Song, Yurong [VerfasserIn] |
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| | Elsaadi, Ali [VerfasserIn] |
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| | Deng, Nan [VerfasserIn] |
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| | Vilar, Eduardo [VerfasserIn] |
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| | Fuchs, Vera [VerfasserIn] |
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| | Nelius, Nina [VerfasserIn] |
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| | Yuan, Yan [VerfasserIn] |
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| | Ahadova, Aysel [VerfasserIn] |
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| | Sei, Shizuko [VerfasserIn] |
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| | Shoemaker, Robert H. [VerfasserIn] |
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| | Umar, Asad [VerfasserIn] |
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| | Wei, Lei [VerfasserIn] |
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| | Liu, Song [VerfasserIn] |
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| | Bork, Peer [VerfasserIn] |
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| | Edelmann, Winfried [VerfasserIn] |
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| | Knebel Doeberitz, Magnus von [VerfasserIn] |
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| | Lipkin, Steven M. [VerfasserIn] |
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| | Kloor, Matthias [VerfasserIn] |
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| Titel: | Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model |
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| Verf.angabe: | Johannes Gebert, Ozkan Gelincik, Mine Oezcan-Wahlbrink, Jason D. Marshall, Alejandro Hernandez-Sanchez, Katharina Urban, Mark Long, Eduardo Cortes, Elena Tosti, Eva M. Katzenmaier, Yurong Song, Ali Elsaadi, Nan Deng, Eduardo Vilar, Vera Fuchs, Nina Nelius, Yan Yuan, Aysel Ahadova, Shizuko Sei, Robert H. Shoemaker, Asad Umar, Lei Wei, Song Liu, Peer Bork, Winfried Edelmann, Magnus von Knebel Doeberitz, Steven M. Lipkin, and Matthias Kloor |
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| E-Jahr: | 2021 |
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| Jahr: | 2 July 2021 |
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| Umfang: | 28 S. |
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| Fussnoten: | Gesehen am 27.07.2021 |
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| Titel Quelle: | Enthalten in: Gastroenterology |
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| Ort Quelle: | Stanford, Calif. : HighWire Press, 1965 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 161(2021), 4 vom: Okt., Seite 1288-1302.e13 |
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| ISSN Quelle: | 1528-0012 |
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| Abstract: | DNA mismatch repair deficiency drives microsatellite instability (MSI). Cells with MSI accumulate numerous frameshift mutations. Frameshift mutations affecting cancer-related genes may promote tumorigenesis and, therefore, are shared among independently arising MSI tumors. Consequently, such recurrent frameshift mutations can give rise to shared immunogenic frameshift peptides (FSPs) that represent ideal candidates for a vaccine against MSI cancer. Pathogenic germline variants of mismatch repair genes cause Lynch syndrome (LS), a hereditary cancer syndrome affecting approximately 20-25 million individuals worldwide. Individuals with LS are at high risk of developing MSI cancer. Previously, we demonstrated safety and immunogenicity of an FSP-based vaccine in a phase I/IIa clinical trial in patients with a history of MSI colorectal cancer. However, the cancer-preventive effect of FSP vaccination in the scenario of LS has not yet been demonstrated. |
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| DOI: | doi:10.1053/j.gastro.2021.06.073 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1053/j.gastro.2021.06.073 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0016508521031875 |
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| | DOI: https://doi.org/10.1053/j.gastro.2021.06.073 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Colorectal Cancer |
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| | Frameshift Neoantigens |
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| | Lynch Syndrome |
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| | Mouse Model |
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| | Preventive Cancer Vaccine |
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| K10plus-PPN: | 1764631846 |
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| Verknüpfungen: | → Zeitschrift |
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Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model / Gebert, Johannes [VerfasserIn]; 2 July 2021 (Online-Ressource)
