αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals

• Verfasst von: Aghaallaei, Nargessadat [VerfasserIn]
• Verfasst von: Dick, Advaita M. [VerfasserIn]
• Verfasst von: Tsingos, Erika [VerfasserIn]
• Verfasst von: Inoue, Daigo [VerfasserIn]
• Verfasst von: Hasel, Eva Mareike [VerfasserIn]
• Verfasst von: Thumberger, Thomas [VerfasserIn]
• Verfasst von: Toyoda, Atsushi [VerfasserIn]
• Verfasst von: Leptin, Maria [VerfasserIn]
• Verfasst von: Wittbrodt, Joachim [VerfasserIn]
• Verfasst von: Bajoghli, Baubak [VerfasserIn]
• Titel: αβ/γδ T cell lineage outcome is regulated by intrathymic cell localization and environmental signals
• Verf.angabe: Narges Aghaallaei, Advaita M. Dick, Erika Tsingos, Daigo Inoue, Eva Hasel, Thomas Thumberger, Atsushi Toyoda, Maria Leptin, Joachim Wittbrodt, Baubak Bajoghli
• E-Jahr: 2021
• Jahr: 14 July 2021
• Umfang: 13 S.
• Teil: volume:7
• Teil: year:2021
• Teil: number:29
• Teil: elocationid:eabg3613
• Teil: pages:1-13
• Teil: extent:13
• Fussnoten: Gesehen am 27.07.2021
• Titel Quelle: Enthalten in: Science advances
• Ort Quelle: Washington, DC [u.a.] : Assoc., 2015
• Jahr Quelle: 2021
• Band/Heft Quelle: 7(2021), 29, Artikel-ID eabg3613, Seite 1-13
• ISSN Quelle: 2375-2548
• DOI: doi:10.1126/sciadv.abg3613
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1764646657

Abstract

αβ and γδ T cells are two distinct sublineages that develop in the vertebrate thymus. Thus far, their differentiation from a common progenitor is mostly understood to be regulated by intrinsic mechanisms. However, the proportion of αβ/γδ T cells varies in different vertebrate taxa. How this process is regulated in species that tend to produce a high frequency of γδ T cells is unstudied. Using an in vivo teleost model, the medaka, we report that progenitors first enter a thymic niche where their development into γδ T cells is favored. Translocation from this niche, mediated by chemokine receptor Ccr9b, is a prerequisite for their differentiation into αβ T cells. On the other hand, the thymic niche also generates opposing gradients of the cytokine interleukin-7 and chemokine Ccl25a, and, together, they influence the lineage outcome. We propose a previously unknown mechanism that determines the proportion of αβ/γδ lineages within species. - The level of γδ T cells varies between species because of differences in cellular dynamics and signals from thymic niche. - The level of γδ T cells varies between species because of differences in cellular dynamics and signals from thymic niche.