| |  Online-Ressource |
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| Verfasst von: | Bailey, Adam L. [VerfasserIn]  |
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| | Dmytrenko, Oleksandr [VerfasserIn] |
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| | Greenberg, Lina [VerfasserIn] |
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| | Bredemeyer, Andrea L. [VerfasserIn] |
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| | Ma, Pan [VerfasserIn] |
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| | Liu, Jing [VerfasserIn] |
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| | Penna, Vinay [VerfasserIn] |
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| | Winkler, Emma S. [VerfasserIn] |
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| | Sviben, Sanja [VerfasserIn] |
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| | Brooks, Erin [VerfasserIn] |
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| | Nair, Ajith P. [VerfasserIn] |
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| | Heck, Kent A. [VerfasserIn] |
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| | Rali, Aniket S. [VerfasserIn] |
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| | Simpson, Leo [VerfasserIn] |
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| | Saririan, Mehrdad [VerfasserIn] |
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| | Hobohm, Dan [VerfasserIn] |
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| | Stump, W. Tom [VerfasserIn] |
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| | Fitzpatrick, James A. [VerfasserIn] |
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| | Xie, Xuping [VerfasserIn] |
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| | Zhang, Xianwen [VerfasserIn] |
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| | Shi, Pei-Yong [VerfasserIn] |
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| | Hinson, J. Travis [VerfasserIn] |
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| | Gi, Weng-Tein [VerfasserIn] |
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| | Schmidt, Constanze [VerfasserIn] |
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| | Leuschner, Florian [VerfasserIn] |
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| | Lin, Chieh-Yu [VerfasserIn] |
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| | Diamond, Michael S. [VerfasserIn] |
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| | Greenberg, Michael J. [VerfasserIn] |
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| | Lavine, Kory J. [VerfasserIn] |
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| Titel: | SARS-CoV-2 infects human engineered heart tissues and models COVID-19 myocarditis |
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| Verf.angabe: | Adam L. Bailey, MD, PHD, Oleksandr Dmytrenko, BA, Lina Greenberg, PHD, Andrea L. Bredemeyer, PHD, Pan Ma, PHD, Jing Liu, MS, Vinay Penna, BS, Emma S. Winkler, BS, Sanja Sviben, PHD, Erin Brooks, MD, Ajith P. Nair, MD, Kent A. Heck, MD, Aniket S. Rali, MD, Leo Simpson, MD, Mehrdad Saririan, MD, Dan Hobohm, MD, W. Tom Stump, PHD, James A. Fitzpatrick, PHD, Xuping Xie, PHD, Xianwen Zhang, PHD, Pei-Yong Shi, PHD, J. Travis Hinson, MD, Weng-Tein Gi, MD, MSC, Constanze Schmidt, MD, Florian Leuschner, MD, Chieh-Yu Lin, MD, PHD, Michael S. Diamond, MD, PHD, Michael J. Greenberg, PHD, Kory J. Lavine, MD, PHD |
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| E-Jahr: | 2021 |
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| Jahr: | April 2021 |
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| Umfang: | 15 S. |
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| Teil: | volume:6 |
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| | year:2021 |
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| | number:4 |
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| | pages:331-345 |
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| | extent:15 |
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| Fussnoten: | Gesehen am 27.07.2021 |
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| Titel Quelle: | Enthalten in: JACC Basic to translational science |
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| Ort Quelle: | Washington, DC : American College of Cardiology, 2016 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 6(2021), 4, Seite 331-345 |
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| ISSN Quelle: | 2452-302X |
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| Abstract: | There is ongoing debate as to whether cardiac complications of coronavirus disease-2019 (COVID-19) result from myocardial viral infection or are secondary to systemic inflammation and/or thrombosis. We provide evidence that cardiomyocytes are infected in patients with COVID-19 myocarditis and are susceptible to severe acute respiratory syndrome coronavirus 2. We establish an engineered heart tissue model of COVID-19 myocardial pathology, define mechanisms of viral pathogenesis, and demonstrate that cardiomyocyte severe acute respiratory syndrome coronavirus 2 infection results in contractile deficits, cytokine production, sarcomere disassembly, and cell death. These findings implicate direct infection of cardiomyocytes in the pathogenesis of COVID-19 myocardial pathology and provides a model system to study this emerging disease. |
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| DOI: | doi:10.1016/j.jacbts.2021.01.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.jacbts.2021.01.002 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2452302X21000127 |
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| | DOI: https://doi.org/10.1016/j.jacbts.2021.01.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cardiomyocyte |
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| | coronavirus disease 2019 |
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| | engineered heart tissue |
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| | myocarditis |
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| | severe acute respiratory syndrome coronavirus 2 |
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| K10plus-PPN: | 1764671155 |
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| Verknüpfungen: | → Zeitschrift |
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SARS-CoV-2 infects human engineered heart tissues and models COVID-19 myocarditis / Bailey, Adam L. [VerfasserIn]; April 2021 (Online-Ressource)
