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| Verfasst von: | Pievani, Alice [VerfasserIn]  |
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| | Savoldelli, Roberto [VerfasserIn] |
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| | Poelchen, Juliane [VerfasserIn] |
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| | Mattioli, Elisa [VerfasserIn] |
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| | Anselmi, Giorgio [VerfasserIn] |
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| | Girardot, Alice [VerfasserIn] |
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| | Utikal, Jochen [VerfasserIn] |
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| | Bourdely, Pierre [VerfasserIn] |
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| | Serafini, Marta [VerfasserIn] |
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| | Guermonprez, Pierre [VerfasserIn] |
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| Titel: | Harnessing mesenchymal stromal cells for the engineering of human hematopoietic niches |
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| Verf.angabe: | Alice Pievani, Roberto Savoldelli, Juliane Poelchen, Elisa Mattioli, Giorgio Anselmi, Alice Girardot, Jochen Utikal, Pierre Bourdely, Marta Serafini and Pierre Guermonprez |
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| E-Jahr: | 2021 |
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| Jahr: | 15 March 2021 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 29.07.2021 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 631279, Seite 1-17 |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | Tissue engineering opens multiple opportunities in regenerative medicine, drug testing and modelling of the hematopoiesis in health and disease. Recapitulating the organization of physiological microenvironments supporting leukocyte development is essential to model faithfully the development of immune cells. Hematopoietic organs are shaped by spatially organized niches defined by multiple cellular contributions. A shared feature of immune niches is the presence of mesenchymal stromal cells endowed with unique roles in organizing niche development, maintenance and function. Here, we review challenges and opportunities in harnessing stromal cells for the engineering of artificial immune niches and hematopoietic organoids recapitulating leukocyte ontogeny both in vitro and in vivo. |
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| DOI: | doi:10.3389/fimmu.2021.631279 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3389/fimmu.2021.631279 |
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| | Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.631279/full |
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| | DOI: https://doi.org/10.3389/fimmu.2021.631279 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | 3D culture |
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| | bone marrow niche |
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| | Hematopoiesis |
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| | mesenchymal stroma cell |
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| | Organoids model |
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| | Thymus epithelial cell |
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| K10plus-PPN: | 176489247X |
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| Verknüpfungen: | → Zeitschrift |
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Harnessing mesenchymal stromal cells for the engineering of human hematopoietic niches / Pievani, Alice [VerfasserIn]; 15 March 2021 (Online-Ressource)
