Igf signaling couples retina growth with body growth by modulating progenitor cell division

• Verfasst von: Becker, Clara [VerfasserIn]
• Verfasst von: Lust, Katharina [VerfasserIn]
• Verfasst von: Wittbrodt, Joachim [VerfasserIn]
• Titel: Igf signaling couples retina growth with body growth by modulating progenitor cell division
• Verf.angabe: Clara Becker, Katharina Lust and Joachim Wittbrodt
• E-Jahr: 2021
• Jahr: 15 April 2021
• Umfang: 13 S.
• Teil: volume:148
• Teil: year:2021
• Teil: number:7
• Teil: elocationid:dev199133
• Teil: pages:1-13
• Teil: extent:13
• Fussnoten: Gesehen am 29.07.2021
• Titel Quelle: Enthalten in: Development <Cambridge>
• Ort Quelle: Cambridge : The Company of Biologists, 1953
• Jahr Quelle: 2021
• Band/Heft Quelle: 148(2021), 7, Artikel-ID dev199133, Seite 1-13
• ISSN Quelle: 1477-9129
• DOI: doi:10.1242/dev.199133
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1764914686

Abstract

How the body and organs balance their relative growth is of key importance for coordinating size and function. This is of particular relevance in organisms, which continue to grow over their entire life span. We addressed this issue in the neuroretina of medaka fish (Oryzias latipes), a well-studied system with which to address vertebrate organ growth. We reveal that a central growth regulator, Igf1 receptor (Igf1r), is necessary and sufficient for proliferation control in the postembryonic retinal stem cell niche: the ciliary marginal zone (CMZ). Targeted activation of Igf1r signaling in the CMZ uncouples neuroretina growth from body size control, and we demonstrate that Igf1r operates on progenitor cells, stimulating their proliferation. Activation of Igf1r signaling increases retinal size while preserving its structural integrity, revealing a modular organization in which progenitor differentiation and neurogenesis are self-organized and highly regulated. Our findings position Igf signaling as a key module for controlling retinal size and composition, with important evolutionary implications.