| |  Online-Ressource |
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| Verfasst von: | Kunadt, Marcel [VerfasserIn]  |
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| | Eckermann, Katrin [VerfasserIn] |
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| | Stuendl, Anne [VerfasserIn] |
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| | Gong, Jing [VerfasserIn] |
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| | Russo, Belisa [VerfasserIn] |
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| | Strauß, Katrin [VerfasserIn] |
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| | Rai, Surya [VerfasserIn] |
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| | Kügler, Sebastian [VerfasserIn] |
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| | Falomir Lockhart, Lisandro [VerfasserIn] |
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| | Schwalbe, Martin [VerfasserIn] |
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| | Krumova, Petranka [VerfasserIn] |
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| | Oliveira, Luis M. A. [VerfasserIn] |
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| | Bähr, Mathias [VerfasserIn] |
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| | Möbius, Wiebke [VerfasserIn] |
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| | Levin, Johannes Martin [VerfasserIn] |
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| | Giese, Armin [VerfasserIn] |
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| | Kruse, Niels [VerfasserIn] |
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| | Mollenhauer, Brit [VerfasserIn] |
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| | Geiss-Friedlander, Ruth [VerfasserIn] |
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| | Ludolph, Albert C. [VerfasserIn] |
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| | Freischmidt, Axel [VerfasserIn] |
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| | Feiler, Marisa S. [VerfasserIn] |
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| | Danzer, Karin M. [VerfasserIn] |
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| | Zweckstetter, Markus [VerfasserIn] |
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| | Jovin, Thomas M. [VerfasserIn] |
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| | Simons, Mikael [VerfasserIn] |
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| | Weishaupt, Jochen H. [VerfasserIn] |
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| | Schneider, Anja [VerfasserIn] |
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| Titel: | Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation |
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| Verf.angabe: | Marcel Kunadt, Katrin Eckermann, Anne Stuendl, Jing Gong, Belisa Russo, Katrin Strauss, Surya Rai, Sebastian Kügler, Lisandro Falomir Lockhart, Martin Schwalbe, Petranka Krumova, Luis M.A. Oliveira, Mathias Bähr, Wiebke Möbius, Johannes Levin, Armin Giese, Niels Kruse, Brit Mollenhauer, Ruth Geiss-Friedlander, Albert C. Ludolph, Axel Freischmidt, Marisa S. Feiler, Karin M. Danzer, Markus Zweckstetter, Thomas M. Jovin, Mikael Simons, Jochen H. Weishaupt, Anja Schneider |
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| E-Jahr: | 2015 |
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| Jahr: | 17 March 2015 |
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| Umfang: | 19 S. |
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| Teil: | volume:129 |
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| | year:2015 |
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| | number:5 |
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| | pages:695-713 |
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| | extent:19 |
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| Fussnoten: | Gesehen am 29.07.2021 |
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| Titel Quelle: | Enthalten in: Acta neuropathologica |
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| Ort Quelle: | Berlin : Springer, 1961 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 129(2015), 5, Seite 695-713 |
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| ISSN Quelle: | 1432-0533 |
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| Abstract: | Extracellular α-Synuclein has been implicated in interneuronal propagation of disease pathology in Parkinson’s Disease. How α-Synuclein is released into the extracellular space is still unclear. Here, we show that α-Synuclein is present in extracellular vesicles in the central nervous system. We find that sorting of α-Synuclein in extracellular vesicles is regulated by sumoylation and that sumoylation acts as a sorting factor for targeting of both, cytosolic and transmembrane proteins, to extracellular vesicles. We provide evidence that the SUMO-dependent sorting utilizes the endosomal sorting complex required for transport (ESCRT) by interaction with phosphoinositols. Ubiquitination of cargo proteins is so far the only known determinant for ESCRT-dependent sorting into the extracellular vesicle pathway. Our study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of α-Synuclein. We deciphered in detail the molecular mechanism which directs α-Synuclein into extracellular vesicles which is of highest relevance for the understanding of Parkinson’s disease pathogenesis and progression at the molecular level. We furthermore propose that sumo-dependent sorting constitutes a mechanism with more general implications for cell biology. |
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| DOI: | doi:10.1007/s00401-015-1408-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00401-015-1408-1 |
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| | DOI: https://doi.org/10.1007/s00401-015-1408-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1764938062 |
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| Verknüpfungen: | → Zeitschrift |
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Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation / Kunadt, Marcel [VerfasserIn]; 17 March 2015 (Online-Ressource)
