Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo

• Verfasst von: Zwicker, Felix [VerfasserIn]
• Verfasst von: Röder, Falk [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Huber, Peter E. [VerfasserIn]
• Verfasst von: Weber, Klaus-Josef [VerfasserIn]
• Titel: Dichloroacetate induces tumor-specific radiosensitivity in vitro but attenuates radiation-induced tumor growth delay in vivo
• Verf.angabe: F. Zwicker, A. Kirsner, P. Peschke, F. Roeder, J. Debus, P.E. Huber, K.J. Weber
• E-Jahr: 2013
• Jahr: 23 June 2013
• Umfang: 9 S.
• Teil: volume:189
• Teil: year:2013
• Teil: number:8
• Teil: pages:684-692
• Teil: extent:9
• Fussnoten: Gesehen am 02.08.2021
• Titel Quelle: Enthalten in: Strahlentherapie und Onkologie
• Ort Quelle: Berlin : Springer Medizin, 1997
• Jahr Quelle: 2013
• Band/Heft Quelle: 189(2013), 8, Seite 684-692
• ISSN Quelle: 1439-099X
• DOI: doi:10.1007/s00066-013-0354-x
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1765239540

Abstract

Inhibition of pyruvate dehydrogenase kinase (PDK) by dichloroacetate (DCA) can shift tumor cell metabolism from anaerobic glycolysis to glucose oxidation, with activation of mitochondrial activity and chemotherapy-dependent apoptosis. In radiotherapy, DCA could thus potentially enhance the frequently moderate apoptotic response of cancer cells that results from their mitochondrial dysfunction. The aim of this study was to investigate tumor-specific radiosensitization by DCA in vitro and in a human tumor xenograft mouse model in vivo.