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| Verfasst von: | Paredes Ugarte, Isidora B. [VerfasserIn]  |
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| | Cruz Vieira, José Ricardo da [VerfasserIn] |
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| | Shah, Bhavin [VerfasserIn] |
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| | Ramunno, Carla F. [VerfasserIn] |
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| | Dyckow, Julia [VerfasserIn] |
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| | Adler, Heike [VerfasserIn] |
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| | Richter, Melanie [VerfasserIn] |
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| | Schermann, Géza [VerfasserIn] |
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| | Giannakouri, Evangelia [VerfasserIn] |
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| | Schirmer, Lucas [VerfasserIn] |
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| | Augustin, Hellmut [VerfasserIn] |
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| | Ruiz de Almodóvar, Carmen [VerfasserIn] |
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| Titel: | Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk |
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| Verf.angabe: | Isidora Paredes, José Ricardo Vieira, Bhavin Shah, Carla F. Ramunno, Julia Dyckow, Heike Adler, Melanie Richter, Geza Schermann, Evangelia Giannakouri, Lucas Schirmer, Hellmut G. Augustin and Carmen Ruiz de Almodóvar |
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| E-Jahr: | 2021 |
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| Jahr: | 28 January 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 02.08.2021 |
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| Titel Quelle: | Enthalten in: Nature neuroscience |
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| Ort Quelle: | New York, NY : Nature America, 1998 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 24(2021), 4, Seite 478-488 |
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| ISSN Quelle: | 1546-1726 |
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| Abstract: | Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification. Mechanistically, we show that neural progenitor cells (NPCs) express angiopoietin-1 (Ang1) and that this expression is regulated by Sonic hedgehog. We demonstrate that NPC-derived Ang1 signals to its receptor, Tie2, on endothelial cells to induce the production of transforming growth factor beta 1 (TGFβ1). Endothelial-derived TGFβ1, in turn, acts as an angiocrine molecule and signals back to NPCs to induce their commitment toward oligodendrocyte precursor cells. This work demonstrates a true bidirectional collaboration between NPCs and the vasculature as a critical regulator of oligodendrogenesis. |
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| DOI: | doi:10.1038/s41593-020-00788-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41593-020-00788-z |
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| | Volltext: https://www.nature.com/articles/s41593-020-00788-z |
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| | DOI: https://doi.org/10.1038/s41593-020-00788-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1765240913 |
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| Verknüpfungen: | → Zeitschrift |
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Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk / Paredes Ugarte, Isidora B. [VerfasserIn]; 28 January 2021 (Online-Ressource)
