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Verfasst von:Fox, Christopher [VerfasserIn]   i
 Dreger, Peter [VerfasserIn]   i
Titel:High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere
Titelzusatz:a study from the European Society for Blood and Marrow Transplantation
Verf.angabe:Christopher P. Fox, Ariane Boumendil, Norbert Schmitz, Herve Finel, Jian J. Luan, Gülsan Sucak, Didier Blaise, Jürgen Finke, Karl-Heinz Pflüger, Hendrik Veelken, Norbert -Claude Gorin, Xavier Poiré, Arnold Ganser, Peter Dreger, Anna Sureda
E-Jahr:2015
Jahr:26 Aug 2015
Umfang:6 S.
Teil:volume:56
 year:2015
 number:12
 pages:3295-3300
 extent:6
Fussnoten:Gesehen am 05.08.2021
Titel Quelle:Enthalten in: Leukemia and lymphoma
Ort Quelle:London [u.a.] : Taylor & Francis Group, 1989
Jahr Quelle:2015
Band/Heft Quelle:56(2015), 12, Seite 3295-3300
ISSN Quelle:1029-2403
Abstract:Extra-nodal NK/T lymphoma (ENKTL) is rare and more frequently encountered in East Asia. The role of high-dose therapy and autologous stem cell transplantation (HDT-ASCT) for ENKTL is unclear. Twenty-eight evaluable patients who had undergone HDT-ASCT in Europe from 2000-2009 were studied. The median age was 47 years and patients had received a median of two lines of prior therapy. Some 57% of patients were not in complete remission or beyond first complete remission at HDT-ASCT. The 1-year non-relapse mortality (NRM) was 11%; 2-year progression-free survival (PFS) and overall survival (OS) rates were 41% and 52%, respectively. Notably, the 2-year PFS and OS for those with stage III/IV disease were 33% and 40%, respectively, with no relapses beyond 1-year post-HDT-ASCT. This is the largest analysis of HDT-ASCT for patients with ENKTL reported from the Western hemisphere. Survival is comparable to East Asian cohorts and outcomes are encouraging for patients with advanced disease.
DOI:doi:10.3109/10428194.2015.1037764
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3109/10428194.2015.1037764
 DOI: https://doi.org/10.3109/10428194.2015.1037764
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Epstein-Barr virus
 high-dose therapy
 natural killer cell lymphoma
 stem cell transplantation
K10plus-PPN:176562827X
Verknüpfungen:→ Zeitschrift

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