| |  Online-Ressource |
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| Verfasst von: | Gao, Xin [VerfasserIn]  |
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| | Zhang, Yan [VerfasserIn] |
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| | Li, Xiangwei [VerfasserIn] |
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| | Jansen, Lina [VerfasserIn] |
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| | Alwers, Elizabeth [VerfasserIn] |
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| | Bewerunge-Hudler, Melanie [VerfasserIn] |
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| | Schick, Matthias [VerfasserIn] |
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| | Chang-Claude, Jenny [VerfasserIn] |
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| | Hoffmeister, Michael [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | DNA methylation-based estimates of circulating leukocyte composition for predicting colorectal cancer survival |
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| Titelzusatz: | a prospective cohort study |
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| Verf.angabe: | Xīn Gào, Yan Zhang, Xiangwei Li, Lina Jansen, Elizabeth Alwers, Melanie Bewerunge-Hudler, Matthias Schick, Jenny Chang-Claude, Michael Hoffmeister and Hermann Brenner |
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| E-Jahr: | 2021 |
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| Jahr: | 12 June 2021 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 05.08.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 12, Artikel-ID 2948, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Leukocytes are involved in the progression of colorectal cancer (CRC). The proportion of six major leukocyte subtypes can be estimated using epigenome-wide DNA methylation (DNAm) data from stored blood samples. Whether the composition of circulating leukocytes can be used as a prognostic factor is unclear. DNAm-based leukocyte proportions were obtained from a prospective cohort of 2206 CRC patients. Multivariate Cox regression models and survival curves were applied to assess associations between leukocyte composition and survival outcomes. A higher proportion of lymphocytes, including CD4+ T cells, CD8+ T cells, B cells, and NK cells, was associated with better survival, while a higher proportion of neutrophils was associated with poorer survival. CD4+ T cells outperformed other leukocytes in estimating the patients’ prognosis. Comparing the highest quantile to the lowest quantile of CD4+ T cells, hazard ratios (95% confidence intervals) of all-cause and CRC-specific mortality were 0.59 (0.48, 0.72) and 0.59 (0.45, 0.77), respectively. Furthermore, the association of CD4+ T cells and prognosis was stronger among patients with early or intermediate CRC or patients with colon cancer. In conclusion, the composition of circulating leukocytes estimated from DNAm, particularly the proportions of CD4+ T cells, could be used as promising independent predictors of CRC survival. |
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| DOI: | doi:10.3390/cancers13122948 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers13122948 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/12/2948 |
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| | DOI: https://doi.org/10.3390/cancers13122948 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | circulating leukocytes |
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| | colorectal cancer |
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| | DNA methylation |
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| | prognosis |
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| K10plus-PPN: | 1765673674 |
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| Verknüpfungen: | → Zeitschrift |
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DNA methylation-based estimates of circulating leukocyte composition for predicting colorectal cancer survival / Gao, Xin [VerfasserIn]; 12 June 2021 (Online-Ressource)
