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Verfasst von:Klupp, Fee [VerfasserIn]   i
 Kahlert, Christoph [VerfasserIn]   i
 Franz, Clemens [VerfasserIn]   i
 Halama, Niels [VerfasserIn]   i
 Schleußner, Nikolai [VerfasserIn]   i
 Wirsik, Naita M. [VerfasserIn]   i
 Warth, Arne [VerfasserIn]   i
 Schmidt, Thomas [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
Titel:Granulin
Titelzusatz:an invasive and survival-determining marker in colorectal cancer patients
Verf.angabe:Fee Klupp, Christoph Kahlert, Clemens Franz, Niels Halama, Nikolai Schleussner, Naita M. Wirsik, Arne Warth, Thomas Schmidt and Alexis B. Ulrich
E-Jahr:2021
Jahr:16 June 2021
Umfang:11 S.
Fussnoten:Gesehen am 05.08.2021
Titel Quelle:Enthalten in: International journal of molecular sciences
Ort Quelle:Basel : Molecular Diversity Preservation International, 2000
Jahr Quelle:2021
Band/Heft Quelle:22(2021), 12, Artikel-ID 6436, Seite 1-11
ISSN Quelle:1422-0067
 1661-6596
Abstract:Background: Granulin is a secreted, glycosylated peptide—originated by cleavage from a precursor protein—which is involved in cell growth, tumor invasion and angiogenesis. However, the specific prognostic impact of granulin in human colorectal cancer has only been studied to a limited extent. Thus, we wanted to assess the expression of granulin in colorectal cancer patients to evaluate its potential as a prognostic biomarker. Methods: Expressional differences of granulin in colorectal carcinoma tissue (n = 94) and corresponding healthy colon mucosa were assessed using qRT-PCR. Immunohistochemistry was performed in colorectal cancer specimens (n = 97), corresponding healthy mucosa (n = 47) and colorectal adenomas (n = 19). Subsequently, the results were correlated with histopathological and clinical patients’ data. HCT-116 cells were transfected with siRNA for invasion and migration assays. Results: Immunohistochemistry and qRT-PCR revealed tumoral over expression of granulin in colorectal cancer specimens compared to corresponding healthy colon mucosa and adenomas. Tumoral overexpression of granulin was associated with a significantly impaired overall survival. Moreover, downregulation of granulin by siRNA significantly diminished the invasive capacities of HCT-116 cells in vitro. Conclusion: Expression of granulin differs in colorectal cancer tissue, adenomas and healthy colon mucosa. Furthermore, granulin features invasive and migrative capabilities and overexpression of granulin correlates with a dismal prognosis. This reveals its potential as a prognostic biomarker and granulin could be a worthwhile molecular target for individualized anticancer therapy.
DOI:doi:10.3390/ijms22126436
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/ijms22126436
 Volltext: https://www.mdpi.com/1422-0067/22/12/6436
 DOI: https://doi.org/10.3390/ijms22126436
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adenomas
 colorectal cancer
 granulin
 GRN
 survival
K10plus-PPN:1765678595
Verknüpfungen:→ Zeitschrift

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