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| Verfasst von: | Gaik, Monika [VerfasserIn]  |
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| | Flemming, Dirk [VerfasserIn] |
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| | Mücke, Norbert [VerfasserIn] |
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| | Fischer, Jessica [VerfasserIn] |
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| | Stelter, Philipp [VerfasserIn] |
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| | Baßler, Jochen [VerfasserIn] |
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| | Hurt, Ed [VerfasserIn] |
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| Titel: | Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold |
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| Verf.angabe: | Monika Gaik, Dirk Flemming, Alexander von Appen, Panagiotis Kastritis, Norbert Mücke, Jessica Fischer, Philipp Stelter, Alessandro Ori, Khanh Huy Bui, Jochen Baßler, Elisar Barbar, Martin Beck, and Ed Hurt |
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| E-Jahr: | 2015 |
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| Jahr: | February 02 2015 |
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| Umfang: | 15 S. |
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| Teil: | volume:208 |
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| | year:2015 |
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| | number:3 |
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| | pages:283-297 |
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| | extent:15 |
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| Fussnoten: | Gesehen am 06.08.2021 |
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| Titel Quelle: | Enthalten in: The journal of cell biology |
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| Ort Quelle: | New York, NY : Rockefeller Univ. Press, 1962 |
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| Jahr Quelle: | 2015 |
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| Band/Heft Quelle: | 208(2015), 3, Seite 283-297 |
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| ISSN Quelle: | 1540-8140 |
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| Abstract: | Nuclear pore complexes (NPCs) are huge assemblies formed from ∼30 different nucleoporins, typically organized in subcomplexes. One module, the conserved Nup82 complex at the cytoplasmic face of NPCs, is crucial to terminate mRNA export. To gain insight into the structure, assembly, and function of the cytoplasmic pore filaments, we reconstituted in yeast the Nup82-Nup159-Nsp1-Dyn2 complex, which was suitable for biochemical, biophysical, and electron microscopy analyses. Our integrative approach revealed that the yeast Nup82 complex forms an unusual asymmetric structure with a dimeric array of subunits. Based on all these data, we developed a three-dimensional structural model of the Nup82 complex that depicts how this module might be anchored to the NPC scaffold and concomitantly can interact with the soluble nucleocytoplasmic transport machinery. |
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| DOI: | doi:10.1083/jcb.201411003 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1083/jcb.201411003 |
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| | DOI: https://doi.org/10.1083/jcb.201411003 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1765880394 |
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| Verknüpfungen: | → Zeitschrift |
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Structural basis for assembly and function of the Nup82 complex in the nuclear pore scaffold / Gaik, Monika [VerfasserIn]; February 02 2015 (Online-Ressource)
