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| Verfasst von: | Osuchowski, Marcin [VerfasserIn]  |
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| | Winkler, Martin Sebastian [VerfasserIn] |
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| | Skirecki, Tomasz [VerfasserIn] |
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| | Cajander, Sara [VerfasserIn] |
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| | Shankar-Hari, Manu [VerfasserIn] |
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| | Lachmann, Gunnar [VerfasserIn] |
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| | Monneret, Guillaume [VerfasserIn] |
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| | Venet, Fabienne [VerfasserIn] |
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| | Bauer, Michael [VerfasserIn] |
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| | Brunkhorst, Frank M [VerfasserIn] |
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| | Weis, Sebastian [VerfasserIn] |
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| | Garcia-Salido, Alberto [VerfasserIn] |
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| | Kox, Matthijs [VerfasserIn] |
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| | Cavaillon, Jean-Marc [VerfasserIn] |
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| | Uhle, Florian [VerfasserIn] |
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| | Weigand, Markus A. [VerfasserIn] |
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| | Flohé, Stefanie B [VerfasserIn] |
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| | Wiersinga, W Joost [VerfasserIn] |
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| | Almansa, Raquel [VerfasserIn] |
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| | de la Fuente, Amanda [VerfasserIn] |
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| | Martin-Loeches, Ignacio [VerfasserIn] |
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| | Meisel, Christian [VerfasserIn] |
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| | Spinetti, Thibaud [VerfasserIn] |
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| | Schefold, Joerg C [VerfasserIn] |
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| | Cilloniz, Catia [VerfasserIn] |
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| | Torres, Antoni [VerfasserIn] |
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| | Giamarellos-Bourboulis, Evangelos J [VerfasserIn] |
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| | Ferrer, Ricard [VerfasserIn] |
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| | Girardis, Massimo [VerfasserIn] |
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| | Cossarizza, Andrea [VerfasserIn] |
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| | Netea, Mihai G [VerfasserIn] |
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| | van der Poll, Tom [VerfasserIn] |
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| | Bermejo-Martín, Jesús F [VerfasserIn] |
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| | Rubio, Ignacio [VerfasserIn] |
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| Titel: | The COVID-19 puzzle |
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| Titelzusatz: | deciphering pathophysiology and phenotypes of a new disease entity |
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| Verf.angabe: | Marcin F Osuchowski, Martin S Winkler, Tomasz Skirecki, Sara Cajander, Manu Shankar-Hari, Gunnar Lachmann, Guillaume Monneret, Fabienne Venet, Michael Bauer, Frank M Brunkhorst, Sebastian Weis, Alberto Garcia-Salido, Matthijs Kox, Jean-Marc Cavaillon, Florian Uhle, Markus A Weigand, Stefanie B Flohé, W Joost Wiersinga, Raquel Almansa, Amanda de la Fuente, Ignacio Martin-Loeches, Christian Meisel, Thibaud Spinetti, Joerg C Schefold, Catia Cilloniz, Antoni Torres, Evangelos J Giamarellos-Bourboulis, Ricard Ferrer, Massimo Girardis, Andrea Cossarizza, Mihai G Netea, Tom van der Poll, Jesús F Bermejo-Martín, Ignacio Rubio |
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| E-Jahr: | 2021 |
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| Jahr: | June 2021 |
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| Umfang: | 21 S. |
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| Fussnoten: | Available online 6 May 2021 ; Gesehen am 09.08.2021 |
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| Titel Quelle: | Enthalten in: The lancet <London> / Respiratory medicine |
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| Ort Quelle: | Oxford : Elsevier, 2013 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 9(2021), 6 vom: Juni, Seite 622-642 |
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| ISSN Quelle: | 2213-2619 |
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| Abstract: | The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with devastating consequences. While the medical community has gained insight into the epidemiology of COVID-19, important questions remain about the clinical complexities and underlying mechanisms of disease phenotypes. Severe COVID-19 most commonly involves respiratory manifestations, although other systems are also affected, and acute disease is often followed by protracted complications. Such complex manifestations suggest that SARS-CoV-2 dysregulates the host response, triggering wide-ranging immuno-inflammatory, thrombotic, and parenchymal derangements. We review the intricacies of COVID-19 pathophysiology, its various phenotypes, and the anti-SARS-CoV-2 host response at the humoral and cellular levels. Some similarities exist between COVID-19 and respiratory failure of other origins, but evidence for many distinctive mechanistic features indicates that COVID-19 constitutes a new disease entity, with emerging data suggesting involvement of an endotheliopathy-centred pathophysiology. Further research, combining basic and clinical studies, is needed to advance understanding of pathophysiological mechanisms and to characterise immuno-inflammatory derangements across the range of phenotypes to enable optimum care for patients with COVID-19. |
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| DOI: | doi:10.1016/S2213-2600(21)00218-6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/S2213-2600(21)00218-6 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2213260021002186 |
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| | DOI: https://doi.org/10.1016/S2213-2600(21)00218-6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1765940354 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ COVID-19 puzzle / Osuchowski, Marcin [VerfasserIn]; June 2021 (Online-Ressource)
