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Verfasst von:Schmidt, Karsten [VerfasserIn]   i
 Živković, Aleksandar [VerfasserIn]   i
 Thiele, Martin [VerfasserIn]   i
 Horter, Johannes [VerfasserIn]   i
 Brenner, Thorsten [VerfasserIn]   i
 Weigand, Markus A. [VerfasserIn]   i
 Kleinschmidt, Stefan [VerfasserIn]   i
 Hofer, Stefan [VerfasserIn]   i
Titel:Point-of-care measured serum cholinesterase activity predicts patient outcome following severe burns
Verf.angabe:Karsten Schmidt, Aleksandar R. Zivkovic, Martin Thiele, Johannes Horter, Thorsten Brenner, Markus A. Weigand, Stefan Kleinschmidt, Stefan Hofer
Jahr:2021
Umfang:10 S.
Fussnoten:Available online 11 November 2020 ; Gesehen am 09.08.2021
Titel Quelle:Enthalten in: Burns
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1974
Jahr Quelle:2021
Band/Heft Quelle:47(2021), 4, Seite 863-872
ISSN Quelle:1879-1409
Abstract:Risk stratification is of utmost importance in burn therapy. However, suitable bedside biomarkers to evaluate the emerging inflammatory response following burn injuries are missing. Serum cholinesterase (butyrylcholinesterase, BChE) has been shown to be a clinically relevant biomarker in acute inflammatory diseases including burns. In this observational cohort study BChE activity was measured by using point-of-care testing (POCT), a novel method in acute burn care. POCT measurements were performed at emergency room admission (ERA) of 35 patients and repeated 12, 24 and 48 h later. All patients or their legal designees gave informed consent. Patients with burn injuries showed sustained BChE activity reduction following hospital admission. BChE activity correlated negatively with burn injury severity, organ failure severity and intensive care unit resource requirements. BChE activity measured at ERA and 12 h later identified survivors and predicted 28-day patient outcome with noninferior efficacy compared to the abbreviated burn severity index (ABSI) scoring. Finally, POCT-measured BChE activity might complement ABSI scoring and possibly improve early risk stratification in acute burn care therapy.
DOI:doi:10.1016/j.burns.2020.10.027
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.burns.2020.10.027
 Volltext: https://www.sciencedirect.com/science/article/pii/S0305417920305763
 DOI: https://doi.org/10.1016/j.burns.2020.10.027
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Burn injury
 Butyrylcholinesterase
 Inflammation
 Point of care testing
 Risk stratification
 serum cholinesterase
K10plus-PPN:176596413X
Verknüpfungen:→ Zeitschrift

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