| |  Online-Ressource |
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| Verfasst von: | Yapa, H. Manisha N. [VerfasserIn]  |
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| | Kim, Hae-Young [VerfasserIn] |
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| | Petoumenos, Kathy [VerfasserIn] |
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| | Post, Frank A. [VerfasserIn] |
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| | Jiamsakul, Awachana [VerfasserIn] |
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| | De Neve, Jan-Walter [VerfasserIn] |
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| | Tanser, Frank [VerfasserIn] |
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| | Iwuji, Collins [VerfasserIn] |
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| | Baisley, Kathy [VerfasserIn] |
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| | Shahmanesh, Maryam [VerfasserIn] |
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| | Pillay, Deenan [VerfasserIn] |
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| | Siedner, Mark J. [VerfasserIn] |
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| | Bärnighausen, Till [VerfasserIn] |
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| | Bor, Jacob [VerfasserIn] |
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| Titel: | CD4+ T-cell count at antiretroviral therapy initiation in the "treat all" era in rural South Africa |
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| Titelzusatz: | an interrupted time series analysis |
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| Verf.angabe: | H. Manisha Yapa, Hae-Young Kim, Kathy Petoumenos, Frank A. Post, Awachana Jiamsakul, Jan-Walter De Neve, Frank Tanser, Collins Iwuji, Kathy Baisley, Maryam Shahmanesh, Deenan Pillay, Mark J. Siedner, Till Bärnighausen, Jacob Bor |
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| E-Jahr: | 2021 |
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| Jahr: | 26 July 2021 |
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| Umfang: | 26 S. |
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| Teil: | year:2021 |
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| | elocationid:ciab650 |
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| | pages:1-26 |
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| | extent:26 |
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| Fussnoten: | Gesehen am 09.08.2021 |
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| Titel Quelle: | Enthalten in: Clinical infectious diseases |
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| Ort Quelle: | Oxford : Oxford Journals, 1992 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | (2021) Artikel-Nummer ciab650, accepted manuscript, Seite 1-26, 26 Seiten |
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| ISSN Quelle: | 1537-6591 |
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| Abstract: | BACKGROUND: South Africa implemented universal test and treat (UTT) in September 2016 in an effort to encourage earlier initiation of antiretroviral therapy (ART). - METHODS: We therefore conducted an interrupted time series (ITS) analysis to assess the impact of UTT on mean CD4 count at ART initiation among adults ≥16 years old attending 17 public sector primary care services in rural South Africa between July 2014 and March 2019. - RESULTS: Among 20,599 individuals (69% women), CD4 counts were available for 74%. Mean CD4 at ART initiation increased from 317.1 cells/μL (95% confidence interval, CI, 308.6 to 325.6)-one to eight months prior to UTT-to 421.0 cells/μL (95% CI 413.0 to 429.0) one to twelve months after UTT, including an immediate increase of 124.2 cells/μL (95% CI 102.2 to 146.1). However, mean CD4 count subsequently fell to 389.5 cells/μL (95% CI 381.8 to 397.1) 13 to 30 months after UTT, but remained above pre-UTT levels. Men initiated ART at lower CD4 counts than women (-118.2 cells/μL, 95% CI -125.5 to -111.0) throughout the study. - CONCLUSIONS: Although UTT led to an immediate increase in CD4 count at ART initiation in this rural community, the long-term effects were modest. More efforts are needed to increase initiation of ART early in HIV infection, particularly among men. |
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| DOI: | doi:10.1093/cid/ciab650 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1093/cid/ciab650 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antiretroviral therapy initiation |
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| | CD4 |
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| | HIV/AIDS |
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| | universal test and treat (UTT) |
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| K10plus-PPN: | 1765980054 |
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| Verknüpfungen: | → Zeitschrift |
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CD4+ T-cell count at antiretroviral therapy initiation in the "treat all" era in rural South Africa / Yapa, H. Manisha N. [VerfasserIn]; 26 July 2021 (Online-Ressource)
