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Verfasst von:Yapa, H. Manisha N. [VerfasserIn]   i
 Kim, Hae-Young [VerfasserIn]   i
 Petoumenos, Kathy [VerfasserIn]   i
 Post, Frank A. [VerfasserIn]   i
 Jiamsakul, Awachana [VerfasserIn]   i
 De Neve, Jan-Walter [VerfasserIn]   i
 Tanser, Frank [VerfasserIn]   i
 Iwuji, Collins [VerfasserIn]   i
 Baisley, Kathy [VerfasserIn]   i
 Shahmanesh, Maryam [VerfasserIn]   i
 Pillay, Deenan [VerfasserIn]   i
 Siedner, Mark J. [VerfasserIn]   i
 Bärnighausen, Till [VerfasserIn]   i
 Bor, Jacob [VerfasserIn]   i
Titel:CD4+ T-cell count at antiretroviral therapy initiation in the "treat all" era in rural South Africa
Titelzusatz:an interrupted time series analysis
Verf.angabe:H. Manisha Yapa, Hae-Young Kim, Kathy Petoumenos, Frank A. Post, Awachana Jiamsakul, Jan-Walter De Neve, Frank Tanser, Collins Iwuji, Kathy Baisley, Maryam Shahmanesh, Deenan Pillay, Mark J. Siedner, Till Bärnighausen, Jacob Bor
E-Jahr:2021
Jahr:26 July 2021
Umfang:26 S.
Teil:year:2021
 elocationid:ciab650
 pages:1-26
 extent:26
Fussnoten:Gesehen am 09.08.2021
Titel Quelle:Enthalten in: Clinical infectious diseases
Ort Quelle:Oxford : Oxford Journals, 1992
Jahr Quelle:2021
Band/Heft Quelle:(2021) Artikel-Nummer ciab650, accepted manuscript, Seite 1-26, 26 Seiten
ISSN Quelle:1537-6591
Abstract:BACKGROUND: South Africa implemented universal test and treat (UTT) in September 2016 in an effort to encourage earlier initiation of antiretroviral therapy (ART). - METHODS: We therefore conducted an interrupted time series (ITS) analysis to assess the impact of UTT on mean CD4 count at ART initiation among adults ≥16 years old attending 17 public sector primary care services in rural South Africa between July 2014 and March 2019. - RESULTS: Among 20,599 individuals (69% women), CD4 counts were available for 74%. Mean CD4 at ART initiation increased from 317.1 cells/μL (95% confidence interval, CI, 308.6 to 325.6)-one to eight months prior to UTT-to 421.0 cells/μL (95% CI 413.0 to 429.0) one to twelve months after UTT, including an immediate increase of 124.2 cells/μL (95% CI 102.2 to 146.1). However, mean CD4 count subsequently fell to 389.5 cells/μL (95% CI 381.8 to 397.1) 13 to 30 months after UTT, but remained above pre-UTT levels. Men initiated ART at lower CD4 counts than women (-118.2 cells/μL, 95% CI -125.5 to -111.0) throughout the study. - CONCLUSIONS: Although UTT led to an immediate increase in CD4 count at ART initiation in this rural community, the long-term effects were modest. More efforts are needed to increase initiation of ART early in HIV infection, particularly among men.
DOI:doi:10.1093/cid/ciab650
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

DOI: https://doi.org/10.1093/cid/ciab650
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:antiretroviral therapy initiation
 CD4
 HIV/AIDS
 universal test and treat (UTT)
K10plus-PPN:1765980054
Verknüpfungen:→ Zeitschrift

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