Status: Bibliographieeintrag
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| Verfasst von: | Muḥammad, Sajjad [VerfasserIn]  |
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| | Chaudhry, Shafqat Rasul [VerfasserIn] |
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| | Dobreva, Gergana [VerfasserIn] |
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| | Lawton, Michael T. [VerfasserIn] |
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| | Niemelä, Mika [VerfasserIn] |
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| | Hänggi, Daniel [VerfasserIn] |
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| Titel: | Vascular macrophages as therapeutic targets to treat intracranial aneurysms |
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| Verf.angabe: | Sajjad Muhammad, Shafqat Rasul Chaudhry, Gergana Dobreva, Michael T. Lawton, Mika Niemelä and Daniel Hänggi |
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| E-Jahr: | 2021 |
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| Jahr: | 08 March 2021 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 11.08.2021 |
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| Titel Quelle: | Enthalten in: Frontiers in immunology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 630381, Seite 1-12 |
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| ISSN Quelle: | 1664-3224 |
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| Abstract: | Aneurysmal subarachnoid hemorrhage (aSAH) is a highly fatal and morbid type of hemorrhagic strokes. Intracranial aneurysms (ICAs) rupture cause subarachnoid hemorrhage. ICAs formation, growth and rupture involves cellular and molecular inflammation. Macrophages orchestrate inflammation in the wall of ICAs. Macrophages generally polarize either into classical inflammatory (M1) or alternatively-activated anti-inflammatory (M2)-phenotype. Macrophage infiltration and polarization towards M1-phenotype increases the risk of aneurysm rupture. Strategies that deplete, inhibit infiltration, ameliorate macrophage inflammation or polarize to M2-type protect against ICAs rupture. However, clinical translational data is still lacking. This review summarizes the contribution of macrophage led inflammation in the aneurysm wall and discuss pharmacological strategies to modulate the macrophageal response during ICAs formation and rupture. |
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| DOI: | doi:10.3389/fimmu.2021.630381 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3389/fimmu.2021.630381 |
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| | Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2021.630381/full |
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| | DOI: https://doi.org/10.3389/fimmu.2021.630381 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Inflammation |
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| | Intracranial aneurysms |
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| | macrophage polarisation |
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| | Macrophages |
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| | Monocytes |
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| | Stroke |
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| | Subarachnoid Hemorrhage |
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| K10plus-PPN: | 1766116329 |
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| Verknüpfungen: | → Zeitschrift |
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Vascular macrophages as therapeutic targets to treat intracranial aneurysms / Muḥammad, Sajjad [VerfasserIn]; 08 March 2021 (Online-Ressource)
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