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| Verfasst von: | Khawaja, Rabia R. [VerfasserIn]  |
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| | Agarwal, Amit [VerfasserIn] |
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| | Fukaya, Masahiro [VerfasserIn] |
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| | Jeong, Hey-Kyeong [VerfasserIn] |
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| | Gross, Scott [VerfasserIn] |
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| | Gonzalez-Fernandez, Estibaliz [VerfasserIn] |
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| | Soboloff, Jonathan [VerfasserIn] |
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| | Bergles, Dwight E. [VerfasserIn] |
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| | Kang, Shin H. [VerfasserIn] |
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| Titel: | GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration |
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| Verf.angabe: | Rabia R. Khawaja, Amit Agarwal, Masahiro Fukaya, Hey-Kyeong Jeong, Scott Gross, Estibaliz Gonzalez-Fernandez, Jonathan Soboloff, Dwight E. Bergles, and Shin H. Kang |
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| E-Jahr: | 2021 |
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| Jahr: | 18 May 2021 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 11.08.2021 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 35(2021), 7, Artikel-ID 109147, Seite 1-15, e1-e6 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Oligodendrocyte precursor cells (OPCs) are essential for developmental myelination and oligodendrocyte regeneration after CNS injury. These progenitors express calcium-permeable AMPA receptors (AMPARs) and form direct synapses with neurons throughout the CNS, but the roles of this signaling are unclear. To enable selective alteration of the properties of AMPARs in oligodendroglia, we generate mice that allow cell-specific overexpression of EGFP-GluA2 in vivo. In healthy conditions, OPC-specific GluA2 overexpression significantly increase their proliferation in an age-dependent manner but did not alter their rate of differentiation into oligodendrocytes. In contrast, after demyelinating brain injury in neonates or adults, higher GluA2 levels promote both OPC proliferation and oligodendrocyte regeneration, but do not prevent injury-induced initial cell loss. These findings indicate that AMPAR GluA2 content regulates the proliferative and regenerative behavior of adult OPCs, serving as a putative target for better myelin repair. |
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| DOI: | doi:10.1016/j.celrep.2021.109147 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2021.109147 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124721004861 |
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| | DOI: https://doi.org/10.1016/j.celrep.2021.109147 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | AMPA receptor |
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| | calcium |
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| | GluA2 |
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| | hypoxic-ischemia |
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| | injury |
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| | oligodendrocyte |
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| | OPC |
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| | remyelination |
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| K10plus-PPN: | 1766152465 |
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| Verknüpfungen: | → Zeitschrift |
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GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration / Khawaja, Rabia R. [VerfasserIn]; 18 May 2021 (Online-Ressource)
