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Status: Bibliographieeintrag

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Verfasst von:Mokry, Theresa [VerfasserIn]   i
 Pantke, Judith [VerfasserIn]   i
 Młynarska-Bujny, Anna [VerfasserIn]   i
 Hasse, Felix [VerfasserIn]   i
 Kuder, Tristan Anselm [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Kauczor, Hans-Ulrich [VerfasserIn]   i
 Rom, Joachim [VerfasserIn]   i
 Bickelhaupt, Sebastian [VerfasserIn]   i
Titel:Diffusivity mapping of the ovaries
Titelzusatz:variability of apparent diffusion and kurtosis variables over the menstrual cycle and influence of oral contraceptives
Verf.angabe:Theresa Mokry, Judith Pantke, Anna Mlynarska-Bujny, Felix Christian Hasse, Tristan Anselm Kuder, Heinz-Peter Schlemmer, Hans-Ulrich Kauczor, Joachim Rom, Sebastian Bickelhaupt
E-Jahr:2021
Jahr:24 April 2021
Umfang:8 S.
Fussnoten:Gesehen am 12.08.2021
Titel Quelle:Enthalten in: Magnetic resonance imaging
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1982
Jahr Quelle:2021
Band/Heft Quelle:80(2021) vom: Juli, Seite 50-57
ISSN Quelle:1873-5894
Abstract:Purpose - We aimed to investigate whether quantitative diffusivity variables of healthy ovaries vary during the menstrual cycle and to evaluate alterations in women using oral contraceptives (OC). - Methods - This prospective study (S-339/2016) included 30 healthy female volunteers, with (n = 15) and without (n = 15) intake of OC between 07/2017 and 09/2019. Participants underwent 3T diffusion-weighted MRI (b-values 0-2000 s/mm2) three times during a menstrual cycle (T1 = day 1-5; T2 = day 7-12; T3 = day 19-24). Both ovaries were manually three-dimensionally segmented on b = 1500 s/mm2; apparent diffusion coefficient (ADC) calculation and kurtosis fitting (Dapp, Kapp) were performed. Differences in ADC, Dapp and Kapp between time points and groups were compared using repeated measures ANOVA and t-test after Shapiro-Wilk and Brown-Forsythe test for normality and equal variance. - Results - In women with a natural menstrual cycle, ADC and kurtosis variables showed significant changes in ovaries with the dominant follicle between T1 vs T2 and T1 vs T3, whilst no differences were observed between T2 vs T3: ADC ± SD for T1 1.524 ± 0.160, T2 1.737 ± 0.160, and T3 1.747 ± 0.241 μm2/ms (p = 0.01 T2 vs T1; p = 1.0 T2 vs T3, p = 0.003 T3 vs T1); Dapp ± SD for T1 2.018 ± 0.140, T2 2.272 ± 0.189, and T3 2.230 ± 0.256 μm2/ms (p = 0.003 T2 vs T1, p = 1.0 T2 vs T3, p = 0.02 T3 vs T1); Kapp ± SD for T1 0.614 ± 0.0339, T2 0.546 ± 0.0637, and T3 0.529 ± 0.0567 (p < 0.001 T2 vs T1, p = 0.86 T2 vs T3, p < 0.001 T3 vs T1). No significant differences were found in the contralateral ovaries or in females taking OC. - Conclusion - Physiological cycle-dependent changes in quantitative diffusivity variables of ovaries should be considered especially when interpreting radiomics analyses in reproductive women.
DOI:doi:10.1016/j.mri.2021.04.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.mri.2021.04.006
 Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X21000643
 DOI: https://doi.org/10.1016/j.mri.2021.04.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cyclic changes
 Diffusion kurtosis imaging
 Diffusion-weighted imaging
 Menstrual cycle
 Oral contraceptives
 Ovary
K10plus-PPN:1766516084
Verknüpfungen:→ Zeitschrift

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