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Status: Bibliographieeintrag

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Verfasst von:Zhou, Jun [VerfasserIn]   i
 Valentini, Erica [VerfasserIn]   i
 Boutros, Michael [VerfasserIn]   i
Titel:Microenvironmental innate immune signaling and cell mechanical responses promote tumor growth
Verf.angabe:Jun Zhou, Erica Valentini, Michael Boutros
E-Jahr:2021
Jahr:June 30, 2021
Umfang:21 S.
Fussnoten:Gesehen am 12.08.2021
Titel Quelle:Enthalten in: Developmental cell
Ort Quelle:Cambridge, Mass. : Cell Press, 2001
Jahr Quelle:2021
Band/Heft Quelle:56(2021), 13, Seite 1884-1899, e1-e5
ISSN Quelle:1878-1551
Abstract:Tissue homeostasis is achieved by balancing stem cell maintenance, cell proliferation and differentiation, as well as the purging of damaged cells. Elimination of unfit cells maintains tissue health; however, the underlying mechanisms driving competitive growth when homeostasis fails, for example, during tumorigenesis, remain largely unresolved. Here, using a Drosophila intestinal model, we find that tumor cells outcompete nearby enterocytes (ECs) by influencing cell adhesion and contractility. This process relies on activating the immune-responsive Relish/NF-kappa B pathway to induce EC delamination and requires a JNK-dependent transcriptional upregulation of the peptidoglycan recognition protein PGRP-LA. Consequently, in organisms with impaired PGRP-LA function, tumor growth is delayed and lifespan extended. Our study identifies a non-cell-autonomous role for a JNK/PGRP-LA/Relish signaling axis in mediating death of neighboring normal cells to facilitate tumor growth. We propose that intestinal tumors "hijack'' innate immune signaling to eliminate enterocytes in order to support their own growth.
DOI:doi:10.1016/j.devcel.2021.06.007
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.devcel.2021.06.007
 Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2 ...
 DOI: https://doi.org/10.1016/j.devcel.2021.06.007
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:regeneration
 drosophila
 expression
 activation
 homeostasis
 life-span
 competition drives
 host-defense
 imd
 tissue
K10plus-PPN:1766532063
Verknüpfungen:→ Zeitschrift

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