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Verfasst von:Sebastian, Alexandra [VerfasserIn]   i
 Pohl, M. F. [VerfasserIn]   i
 Klöppel, S. [VerfasserIn]   i
 Feige, B. [VerfasserIn]   i
 Lange, T. [VerfasserIn]   i
 Stahl, C. [VerfasserIn]   i
 Voß, Andreas [VerfasserIn]   i
 Klauer, K. C. [VerfasserIn]   i
 Lieb, K. [VerfasserIn]   i
 Tüscher, O. [VerfasserIn]   i
Titel:Disentangling common and specific neural subprocesses of response inhibition
Verf.angabe:A. Sebastian, M.F. Pohl, S. Klöppel, B. Feige, T. Lange, C. Stahl, A. Voss, K.C. Klauer, K. Lieb, O. Tüscher
Jahr:2013
Umfang:15 S.
Teil:volume:64
 year:2013
 pages:601-615
 extent:15
Fussnoten:Available online 14 September 2012 ; Gesehen am 12.08.2021
Titel Quelle:Enthalten in: NeuroImage
Ort Quelle:Orlando, Fla. : Academic Press, 1992
Jahr Quelle:2013
Band/Heft Quelle:64(2013), Seite 601-615
ISSN Quelle:1095-9572
Abstract:Response inhibition is disturbed in several disorders sharing impulse control deficits as a core symptom. Since response inhibition is a cognitively and neurally multifaceted function which has been shown to rely on differing neural subprocesses and neurotransmitter systems, further differentiation to define neurophysiological endophenotypes is essential. Response inhibition may involve at least three separable cognitive subcomponents, i.e. interference inhibition, action withholding, and action cancelation. Here, we introduce a novel paradigm - the Hybrid Response Inhibition task - to disentangle interference inhibition, action withholding and action cancelation and their neural subprocesses within one task setting during functional magnetic resonance imaging (fMRI). To validate the novel task, results were compared to a battery of separate, standard response inhibition tasks independently capturing these subcomponents and subprocesses. Across all subcomponents, mutual activation was present in the right inferior frontal cortex (rIFC), pre-supplementary motor area (pre-SMA) and parietal regions. Interference inhibition revealed stronger activation in pre-motor and parietal regions. Action cancelation resulted in stronger activation in fronto-striatal regions. Our results show that all subcomponents share a common neural network and thus all constitute different subprocesses of response inhibition. Subprocesses, however, differ to the degree of regional involvement: interference inhibition relies more pronouncedly on a fronto-parietal-pre-motor network suggesting its close relation to response selection processes. Action cancelation, in turn, is more strongly associated with the fronto-striatal pathway implicating it as a late subcomponent of response inhibition. The new paradigm reliably captures three putatively subsequent subprocesses of response inhibition and might be a promising tool to differentially assess disturbed neural networks in disorders showing impulse control deficits.
DOI:doi:10.1016/j.neuroimage.2012.09.020
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.neuroimage.2012.09.020
 Volltext: https://www.sciencedirect.com/science/article/pii/S1053811912009305
 DOI: https://doi.org/10.1016/j.neuroimage.2012.09.020
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Disentangling common and specific neural subprocesses of response inhibition. - 2013
Sach-SW:Go/no-go task
 Impulse control
 Inferior frontal gyrus
 Pre-supplementary motor area
 Simon task
 Stop-signal task
K10plus-PPN:176653693X
Verknüpfungen:→ Zeitschrift

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