| |  Online-Ressource |
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| Verfasst von: | Seib, Désirée Rosa Maria [VerfasserIn]  |
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| | Corsini, Nina S. [VerfasserIn] |
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| | Ellwanger, Kristina [VerfasserIn] |
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| | Plaas, Christian [VerfasserIn] |
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| | Mateos, Alvaro [VerfasserIn] |
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| | Pitzer, Claudia [VerfasserIn] |
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| | Niehrs, Christof [VerfasserIn] |
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| | Celikel, Tansu [VerfasserIn] |
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| | Martín-Villalba, Ana [VerfasserIn] |
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| Titel: | Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline |
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| Verf.angabe: | Désirée R.M. Seib, Nina S. Corsini, Kristina Ellwanger, Christian Plaas, Alvaro Mateos, Claudia Pitzer, Christof Niehrs, Tansu Celikel, and Ana Martin-Villalba |
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| E-Jahr: | 2013 |
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| Jahr: | 7 February 2013 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 12.08.2021 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 12(2013), 2, Seite 204-214 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Memory impairment has been associated with age-related decline in adult hippocampal neurogenesis. Although Notch, bone morphogenetic protein, and Wnt signaling pathways are known to regulate multiple aspects of adult neural stem cell function, the molecular basis of declining neurogenesis in the aging hippocampus remains unknown. Here, we show that expression of the Wnt antagonist Dickkopf-1 (Dkk1) increases with age and that its loss enhances neurogenesis in the hippocampus. Neural progenitors with inducible loss of Dkk1 increase their Wnt activity, which leads to enhanced self-renewal and increased generation of immature neurons. This Wnt-expanded progeny subsequently matures into glutamatergic granule neurons with increased dendritic complexity. As a result, mice deficient in Dkk1 exhibit enhanced spatial working memory and memory consolidation and also show improvements in affective behavior. Taken together, our findings show that upregulating Wnt signaling by reducing Dkk1 expression can counteract age-related decrease in neurogenesis and its associated cognitive decline. |
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| DOI: | doi:10.1016/j.stem.2012.11.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.stem.2012.11.010 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1934590912006443 |
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| | DOI: https://doi.org/10.1016/j.stem.2012.11.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1766558275 |
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| Verknüpfungen: | → Zeitschrift |
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Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline / Seib, Désirée Rosa Maria [VerfasserIn]; 7 February 2013 (Online-Ressource)
