| |  Online-Ressource |
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| Verfasst von: | Raut, Janhavi R. [VerfasserIn]  |
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| | Schöttker, Ben [VerfasserIn] |
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| | Holleczek, Bernd [VerfasserIn] |
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| | Guo, Feng [VerfasserIn] |
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| | Bhardwaj, Megha [VerfasserIn] |
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| | Miah, Kaya [VerfasserIn] |
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| | Schrotz-King, Petra [VerfasserIn] |
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| | Brenner, Hermann [VerfasserIn] |
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| Titel: | A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction |
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| Verf.angabe: | Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King & Hermann Brenner |
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| E-Jahr: | 2021 |
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| Jahr: | 10 August 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 17.08.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 4811, Seite 1-9 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Circulating microRNAs (miRNAs) could improve colorectal cancer (CRC) risk prediction. Here, we derive a blood-based miRNA panel and evaluate its ability to predict CRC occurrence in a population-based cohort of adults aged 50-75 years. Forty-one miRNAs are preselected from independent studies and measured by quantitative-real-time-polymerase-chain-reaction in serum collected at baseline of 198 participants who develop CRC during 14 years of follow-up and 178 randomly selected controls. A 7-miRNA score is derived by logistic regression. Its predictive ability, quantified by the optimism-corrected area-under-the-receiver-operating-characteristic-curve (AUC) using .632+ bootstrap is 0.794. Predictive ability is compared to that of an environmental risk score (ERS) based on known risk factors and a polygenic risk score (PRS) based on 140 previously identified single-nucleotide-polymorphisms. In participants with all scores available, optimism-corrected-AUC is 0.802 for the 7-miRNA score, while AUC (95% CI) is 0.557 (0.498-0.616) for the ERS and 0.622 (0.564-0.681) for the PRS. |
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| DOI: | doi:10.1038/s41467-021-25067-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-021-25067-8 |
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| | Volltext: https://www.nature.com/articles/s41467-021-25067-8 |
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| | DOI: https://doi.org/10.1038/s41467-021-25067-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 176717229X |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction / Raut, Janhavi R. [VerfasserIn]; 10 August 2021 (Online-Ressource)
