Predictors of weight loss in participants with obesity following bariatric surgery

• Verfasst von: Bach, Patrick [VerfasserIn]
• Verfasst von: Großhans, Martin [VerfasserIn]
• Verfasst von: Koopmann, Anne [VerfasserIn]
• Verfasst von: Pfeifer, Anna-Maria [VerfasserIn]
• Verfasst von: Vollstädt-Klein, Sabine [VerfasserIn]
• Verfasst von: Otto, Mirko [VerfasserIn]
• Verfasst von: Kienle, Peter [VerfasserIn]
• Verfasst von: Bumb, Jan Malte [VerfasserIn]
• Verfasst von: Kiefer, Falk [VerfasserIn]
• Titel: Predictors of weight loss in participants with obesity following bariatric surgery
• Titelzusatz: a prospective longitudinal fMRI study
• Verf.angabe: Patrick Bach, Martin Grosshans, Anne Koopmann, Anna-Maria Pfeifer, Sabine Vollstädt-Klein, Mirko Otto, Peter Kienle, J. Malte Bumb, Falk Kiefer
• E-Jahr: 2021
• Jahr: 1 August 2021
• Umfang: 9 S.
• Fussnoten: Gesehen am 18.08.2021
• Titel Quelle: Enthalten in: Appetite
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1980
• Jahr Quelle: 2021
• Band/Heft Quelle: 163(2021), Artikel-ID 105237, Seite 1-9
• ISSN Quelle: 1095-8304
• DOI: doi:10.1016/j.appet.2021.105237
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Amygdala
• Sach-SW: Craving
• Sach-SW: Orbitofrontal cortex
• Sach-SW: Roux-en-Y gastric Bypass
• Sach-SW: Sleeve gastrectomy
• Sach-SW: Yale food addiction scale
• K10plus-PPN: 1767277938

Abstract

Prevalence rates of overweight and obesity are increasing worldwide and are amongst the leading causes of death. Participants with obesity also suffer from poorer mental health with a concomitant reduced quality of life. Bariatric surgery outperforms other existing weight optimization approaches. However, hitherto, it was not possible to identify factors predicting weight loss following surgery. Therefore, we aimed at investigating neural and behavioral predictors of weight loss, as well as the neurological underpinnings of food cue-induced craving before and after bariatric surgery. The total sample consisted of 26 participants with obesity (17 females and 9 males, mean age 41 ± 12 years, mean BMI 46 ± 6 kg/m2, 21 received Roux-en-Y gastric bypass and 5 sleeve gastrectomy). Participants with obesity were prospectively assessed using functional magnetic resonance imaging two weeks before, as well as eight and 24 weeks after surgery. Imaging data were available for 11 individuals; 10 received Roux-en-Y gastric bypass and one sleeve gastrectomy. Subjective cue-induced food craving correlated positively with brain activation in the amygdala, the parahippocampal gyrus, and hippocampus, and negatively with brain activation in frontal brain regions. In the total sample (N = 26), perceived feeling of hunger and YFAS sum score explained 50.6% of the variance (R2 = 0.506, F(1,23) = 10.759, p < 0.001) and in the imaging sample, cue-induced food craving at baseline before surgery explained 49.6% of the variance (R2 = 0.496, F(1,23) = 7.862, p = 0.023) of % total weight loss (%TWL). In other words, with respect to %TWL, bariatric surgery was most efficient in candidates characterized by high cue-induced food craving, high-perceived feeling of hunger and a low YFAS sum score.