| |  Online-Ressource |
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| Verfasst von: | Afanasyeva, Elena [VerfasserIn]  |
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| | Gartlgruber, Moritz [VerfasserIn] |
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| | Ryl, Tatsiana [VerfasserIn] |
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| | Decaesteker, Bieke [VerfasserIn] |
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| | Denecker, Geertrui [VerfasserIn] |
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| | Mönke, Gregor [VerfasserIn] |
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| | Toprak, Umut [VerfasserIn] |
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| | Flórez, Andrés [VerfasserIn] |
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| | Torkov, Alica [VerfasserIn] |
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| | Dreidax, Daniel [VerfasserIn] |
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| | Herrmann, Carl [VerfasserIn] |
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| | Okonechnikov, Konstantin [VerfasserIn] |
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| | Ek, Sara [VerfasserIn] |
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| | Sharma, Ashwini Kumar [VerfasserIn] |
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| | Sagulenko, Vitaliya [VerfasserIn] |
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| | Speleman, Frank [VerfasserIn] |
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| | Henrich, Kai-Oliver [VerfasserIn] |
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| | Westermann, Frank [VerfasserIn] |
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| Titel: | Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma |
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| Verf.angabe: | Elena A Afanasyeva, Moritz Gartlgruber, Tatsiana Ryl, Bieke Decaesteker, Geertrui Denecker, Gregor Moenke, Umut H Toprak, Andres Florez, Alica Torkov, Daniel Dreidax, Carl Herrmann, Konstantin Okonechnikov, Sara Ek, Ashwini Kumar Sharma, Vitaliya Sagulenko, Frank Speleman, Kai-Oliver Henrich, Frank Westermann |
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| E-Jahr: | 2021 |
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| Jahr: | 3 March, 2021 |
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| Umfang: | 25 S. |
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| Teil: | volume:4 |
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| | year:2021 |
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| | number:5 |
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| | elocationid:e201900332 |
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| | pages:1-25 |
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| | extent:25 |
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| Fussnoten: | Gesehen am 19.08.2021 |
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| Titel Quelle: | Enthalten in: Life science alliance |
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| Ort Quelle: | Heidelberg : EMBO Press, 2018 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 4(2021), 5, Artikel-ID e201900332, Seite 1-25 |
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| ISSN Quelle: | 2575-1077 |
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| Abstract: | The migrational propensity of neuroblastoma is affected by cell identity, but the mechanisms behind the divergence remain unknown. Using RNAi and time-lapse imaging, we show that ADRN-type NB cells exhibit RAC1- and kalirin-dependent nucleokinetic (NUC) migration that relies on several integral components of neuronal migration. Inhibition of NUC migration by RAC1 and kalirin-GEF1 inhibitors occurs without hampering cell proliferation and ADRN identity. Using three clinically relevant expression dichotomies, we reveal that most of up-regulated mRNAs in RAC1- and kalirin-GEF1-suppressed ADRN-type NB cells are associated with low-risk characteristics. The computational analysis shows that, in a context of overall gene set poverty, the upregulomes in RAC1- and kalirin-GEF1-suppressed ADRN-type cells are a batch of AU-rich element-containing mRNAs, which suggests a link between NUC migration and mRNA stability. Gene set enrichment analysis-based search for vulnerabilities reveals prospective weak points in RAC1- and kalirin-GEF1-suppressed ADRN-type NB cells, including activities of H3K27- and DNA methyltransferases. Altogether, these data support the introduction of NUC inhibitors into cancer treatment research. |
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| DOI: | doi:10.26508/lsa.201900332 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.26508/lsa.201900332 |
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| | Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.26508% ... |
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| | DOI: https://doi.org/10.26508/lsa.201900332 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | chromatin immunoprecipitation |
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| | coffin-siris syndrome |
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| | cytoplasmic dilation |
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| | doublecortin-like kinase |
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| | messenger-rnas |
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| | neuronal migration |
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| | nuclear-movement |
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| | spindle orientation |
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| | stem-cells |
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| | transcription factors |
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| K10plus-PPN: | 1767452357 |
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| Verknüpfungen: | → Zeitschrift |
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Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma / Afanasyeva, Elena [VerfasserIn]; 3 March, 2021 (Online-Ressource)
