Is there a role for cellular therapy in chronic lymphocytic leukemia?

• Verfasst von: Dreger, Peter [VerfasserIn]
• Titel: Is there a role for cellular therapy in chronic lymphocytic leukemia?
• Verf.angabe: Peter Dreger
• Jahr: 2021
• Umfang: 9 S.
• Teil: volume:27
• Teil: year:2021
• Teil: number:4
• Teil: pages:297-305
• Teil: extent:9
• Fussnoten: Gesehen am 22.08.2021
• Titel Quelle: Enthalten in: The cancer journal
• Ort Quelle: [S.l.] : Lippincott, Williams & Wilkins, 2000
• Jahr Quelle: 2021
• Band/Heft Quelle: 27(2021), 4, Seite 297-305
• ISSN Quelle: 1540-336X
• DOI: doi:10.1097/PPO.0000000000000532
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1767637799

Abstract

Despite multiple advances in the treatment landscape of chronic lymphocytic leukemia (CLL) during recent years, cellular therapies, such as allogeneic hematopoietic cell transplantation and chimeric antigen-engineered T cells, represent valuable therapeutic options for patients with multiply relapsed or poor-risk disease. This brief overview will summarize current results of cellular therapies in CLL including Richter transformation, suggest an indication algorithm and strategies for performing cellular therapies in these conditions, and discuss the impact of COVID-19 (coronavirus disease 2019) on allogeneic hematopoietic cell transplantation and chimeric antigen-engineered T cells in CLL.