| |  Online-Ressource |
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| Verfasst von: | Leupold, Dieter [VerfasserIn]  |
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| | Pfeifer, Lutz [VerfasserIn] |
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| | Hofmann, Maja [VerfasserIn] |
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| | Forschner, Andrea [VerfasserIn] |
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| | Wessler, Gerd [VerfasserIn] |
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| | Hänßle, Holger [VerfasserIn] |
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| Titel: | From melanocytes to melanoma cells |
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| Titelzusatz: | characterization of the malignant transformation by four distinctly different melanin fluorescence spectra (review) |
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| Verf.angabe: | Dieter Leupold, Lutz Pfeifer, Maja Hofmann, Andrea Forschner, Gerd Wessler and Holger Haenssle |
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| E-Jahr: | 2021 |
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| Jahr: | 17 May 2021 |
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| Umfang: | 11 S. |
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| Teil: | volume:22 |
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| | year:2021 |
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| | number:10 |
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| | day:17 |
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| | month:05 |
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| | elocationid:5265 |
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| | pages:1-11 |
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| | extent:11 |
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| Fussnoten: | Gesehen am 23.08.2021 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 22(2021), 10 vom: 17. Mai, Artikel-ID 5265, Seite 1-11 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | The melanin fluorescence emitted by pigment cells of the human skin has been a central research topic for decades, because melanin, on the one hand, protects against (solar) radiation in the near-UV range, whereas on the other hand, melanocytes are the starting point for the malignant transformation into melanoma. Until recently, however, melanin fluorescence was not accessible in the context of conventional spectroscopy, because it is ultraweak and is overshadowed by the more intense so-called autofluorescence of endogenous fluorophores. The advent of a new method of laser spectroscopy has made this melanin fluorescence measurable in vivo. A stepwise two-photon absorption with 800 nm photons is used, which more selectively excites melanin (dermatofluoroscopy). Our review summarizes the experimental results on melanin fluorescence of the four types of cutaneous pigment cells from healthy and malignant tissues. Outstanding is the finding that different types of melanocytes (i.e., melanocytes of common nevi, versus dysplastic nevi or versus melanoma cells) show characteristically different fluorescence spectra. The possibilities of using this melanin fluorescence for melanoma diagnosis are shown. Moreover, the uniform fluorescence spectra emitted by different melanoma subtypes are essential. Conclusions are drawn about the molecular processes in the melanosomes that determine fluorescence. Finally, experimental suggestions for further investigations are given. |
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| DOI: | doi:10.3390/ijms22105265 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/ijms22105265 |
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| | Volltext: https://www.mdpi.com/1422-0067/22/10/5265 |
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| | DOI: https://doi.org/10.3390/ijms22105265 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | dermatofluoroscopy |
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| | dysplastic nevi |
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| | melanin fluorescence |
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| | melanoma subtypes |
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| K10plus-PPN: | 1767688741 |
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| Verknüpfungen: | → Zeitschrift |
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From melanocytes to melanoma cells / Leupold, Dieter [VerfasserIn]; 17 May 2021 (Online-Ressource)
